POLL

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), lambda

PDB rendering based on 1nzp.

Available structures: 1nzp, 1rzt, 1xsl, 1xsn, 1xsp, 2bcq, 2bcr, 2bcs, 2bcu, 2bcv, 2gws, 2pfn, 2pfo, 2pfp, 2pfq

Identifiers

Symbol(s)

POLL; BETA-N; FLJ46002; POL-KAPPA

External IDs

OMIM: 606343 MGI: 1889000 HomoloGene: 40863

Gene ontology
Molecular Function:	• DNA binding • beta DNA polymerase activity • lambda DNA polymerase activity • transferase activity • lyase activity • manganese ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• DNA replication • DNA repair • nucleotide-excision repair • somatic hypermutation of immunoglobulin genes

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013274 (mRNA)
NP_037406 (protein)

NM_020032 (mRNA)
NP_064416 (protein)

Location

Chr 10: 103.33 - 103.34 Mb

Chr 19: 45.61 - 45.61 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), lambda, also known as POLL, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLL polymerase (DNA directed), lambda.

[edit] Further reading

Niida H, Nakanishi M (2002). "[A novel mammalian DNA polymerase: DNA polymerase lambda (pol lambda)]". Seikagaku 74 (3): 224–6. PMID 11974915.
Nagasawa K, Kitamura K, Yasui A, et al. (2000). "Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta -related enzyme.". J. Biol. Chem. 275 (40): 31233–8. doi:10.1074/jbc.M004263200. PMID 10887191.
García-Díaz M, Domínguez O, López-Fernández LA, et al. (2000). "DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis.". J. Mol. Biol. 301 (4): 851–67. doi:10.1006/jmbi.2000.4005. PMID 10966791.
Aoufouchi S, Flatter E, Dahan A, et al. (2000). "Two novel human and mouse DNA polymerases of the polX family.". Nucleic Acids Res. 28 (18): 3684–93. PMID 10982892.
García-Díaz M, Bebenek K, Kunkel TA, Blanco L (2001). "Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair.". J. Biol. Chem. 276 (37): 34659–63. doi:10.1074/jbc.M106336200. PMID 11457865.
Haracska L, Unk I, Johnson RE, et al. (2002). "Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.". Mol. Cell. Biol. 22 (3): 784–91. PMID 11784855.
García-Díaz M, Bebenek K, Sabariegos R, et al. (2002). "DNA polymerase lambda, a novel DNA repair enzyme in human cells.". J. Biol. Chem. 277 (15): 13184–91. doi:10.1074/jbc.M111601200. PMID 11821417.
Shimazaki N, Yoshida K, Kobayashi T, et al. (2003). "Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme.". Genes Cells 7 (7): 639–51. PMID 12081642.
Maga G, Villani G, Ramadan K, et al. (2003). "Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.". J. Biol. Chem. 277 (50): 48434–40. doi:10.1074/jbc.M206889200. PMID 12368291.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ramadan K, Maga G, Shevelev IV, et al. (2003). "Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.". J. Mol. Biol. 328 (1): 63–72. PMID 12683997.
Blanca G, Shevelev I, Ramadan K, et al. (2003). "Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.". Biochemistry 42 (24): 7467–76. doi:10.1021/bi034198m. PMID 12809503.
Bebenek K, Garcia-Diaz M, Blanco L, Kunkel TA (2003). "The frameshift infidelity of human DNA polymerase lambda. Implications for function.". J. Biol. Chem. 278 (36): 34685–90. doi:10.1074/jbc.M305705200. PMID 12829698.
DeRose EF, Kirby TW, Mueller GA, et al. (2003). "Solution structure of the lyase domain of human DNA polymerase lambda.". Biochemistry 42 (32): 9564–74. doi:10.1021/bi034298s. PMID 12911298.
Lee JW, Blanco L, Zhou T, et al. (2004). "Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.". J. Biol. Chem. 279 (1): 805–11. doi:10.1074/jbc.M307913200. PMID 14561766.
Shevelev I, Blanca G, Villani G, et al. (2004). "Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.". Nucleic Acids Res. 31 (23): 6916–25. PMID 14627824.
Guo C, Fischhaber PL, Luk-Paszyc MJ, et al. (2004). "Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis.". EMBO J. 22 (24): 6621–30. doi:10.1093/emboj/cdg626. PMID 14657033.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Garcia-Diaz M, Bebenek K, Krahn JM, et al. (2004). "A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.". Mol. Cell 13 (4): 561–72. PMID 14992725.