POLI

From Wikipedia, the free encyclopedia

Polymerase (DNA directed) iota

PDB rendering based on 1t3n.

Available structures: 1t3n, 1zet, 2alz, 2dpi, 2dpj, 2fll, 2fln, 2flp

Identifiers

Symbol(s)

POLI; RAD30B; RAD3OB

External IDs

OMIM: 605252 MGI: 1347081 HomoloGene: 5209

Gene ontology
Molecular Function:	• magnesium ion binding • DNA binding • iota DNA polymerase activity • transferase activity
Cellular Component:	• intracellular • nucleus • nucleoplasm
Biological Process:	• DNA replication • DNA repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007195 (mRNA)
NP_009126 (protein)

NM_011972 (mRNA)
NP_036102 (protein)

Location

Chr 18: 50.05 - 50.08 Mb

Chr 18: 70.63 - 70.66 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed) iota, also known as POLI, is a human gene.

[edit] Further reading

McDonald JP, Tissier A, Frank EG, et al. (2001). "DNA polymerase iota and related rad30-like enzymes.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 356 (1405): 53–60. doi:10.1098/rstb.2000.0748. PMID 11205331.
Tissier A, Frank EG, McDonald JP, et al. (2001). "Biochemical characterization of human DNA polymerase iota provides clues to its biological function.". Biochem. Soc. Trans. 29 (Pt 2): 183–7. PMID 11356150.
McDonald JP, Rapić-Otrin V, Epstein JA, et al. (1999). "Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.". Genomics 60 (1): 20–30. doi:10.1006/geno.1999.5906. PMID 10458907.
Masutani C, Kusumoto R, Iwai S, Hanaoka F (2000). "Mechanisms of accurate translesion synthesis by human DNA polymerase eta.". EMBO J. 19 (12): 3100–9. doi:10.1093/emboj/19.12.3100. PMID 10856253.
Tissier A, McDonald JP, Frank EG, Woodgate R (2000). "poliota, a remarkably error-prone human DNA polymerase.". Genes Dev. 14 (13): 1642–50. PMID 10887158.
Tissier A, Frank EG, McDonald JP, et al. (2000). "Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota.". EMBO J. 19 (19): 5259–66. doi:10.1093/emboj/19.19.5259. PMID 11013228.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Bebenek K, Tissier A, Frank EG, et al. (2001). "5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro.". Science 291 (5511): 2156–9. doi:10.1126/science.1058386. PMID 11251121.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Frank EG, Tissier A, McDonald JP, et al. (2001). "Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.". EMBO J. 20 (11): 2914–22. doi:10.1093/emboj/20.11.2914. PMID 11387224.
Vaisman A, Tissier A, Frank EG, et al. (2001). "Human DNA polymerase iota promiscuous mismatch extension.". J. Biol. Chem. 276 (33): 30615–22. doi:10.1074/jbc.M102694200. PMID 11402031.
Ohmori H, Friedberg EC, Fuchs RP, et al. (2001). "The Y-family of DNA polymerases.". Mol. Cell 8 (1): 7–8. PMID 11515498.
Vaisman A, Woodgate R (2002). "Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines.". EMBO J. 20 (22): 6520–9. doi:10.1093/emboj/20.22.6520. PMID 11707422.
Faili A, Aoufouchi S, Flatter E, et al. (2002). "Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.". Nature 419 (6910): 944–7. doi:10.1038/nature01117. PMID 12410315.
Kannouche P, Fernández de Henestrosa AR, Coull B, et al. (2003). "Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.". EMBO J. 21 (22): 6246–56. PMID 12426396.
Frank EG, Sayer JM, Kroth H, et al. (2002). "Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota.". Nucleic Acids Res. 30 (23): 5284–92. PMID 12466554.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.