POLH

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), eta

PDB rendering based on 2i5o.

Available structures: 2i5o

Identifiers

Symbol(s)

POLH; FLJ16395; FLJ21978; RAD30A; XP-V; XPV

External IDs

OMIM: 603968 MGI: 1891457 HomoloGene: 38189

Gene ontology
Molecular Function:	• magnesium ion binding • damaged DNA binding • eta DNA polymerase activity • nu DNA polymerase activity • transferase activity
Cellular Component:	• nucleus • nucleoplasm
Biological Process:	• DNA replication • DNA repair • regulation of DNA repair • pyrimidine dimer repair • postreplication repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006502 (mRNA)
NP_006493 (protein)

XM_001002709 (mRNA)
XP_001002709 (protein)

Location

Chr 6: 43.65 - 43.69 Mb

Chr 17: 45.63 - 45.67 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), eta, also known as POLH, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLH polymerase (DNA directed), eta.

[edit] Further reading

Masutani C, Kusumoto R, Yamada A, et al. (1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.". Nature 399 (6737): 700–4. doi:10.1038/21447. PMID 10385124.
Johnson RE, Kondratick CM, Prakash S, Prakash L (1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum.". Science 285 (5425): 263–5. PMID 10398605.
Masutani C, Kusumoto R, Iwai S, Hanaoka F (2000). "Mechanisms of accurate translesion synthesis by human DNA polymerase eta.". EMBO J. 19 (12): 3100–9. doi:10.1093/emboj/19.12.3100. PMID 10856253.
Yamada A, Masutani C, Iwai S, Hanaoka F (2000). "Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta.". Nucleic Acids Res. 28 (13): 2473–80. PMID 10871396.
Yuasa M, Masutani C, Eki T, Hanaoka F (2000). "Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene.". Oncogene 19 (41): 4721–8. doi:10.1038/sj.onc.1203842. PMID 11032022.
Itoh T, Linn S, Kamide R, et al. (2001). "Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation.". J. Invest. Dermatol. 115 (6): 981–5. doi:10.1046/j.1523-1747.2000.00154.x. PMID 11121129.
Zeng X, Winter DB, Kasmer C, et al. (2001). "DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.". Nat. Immunol. 2 (6): 537–41. doi:10.1038/88740. PMID 11376341.
Matsuda T, Bebenek K, Masutani C, et al. (2001). "Error rate and specificity of human and murine DNA polymerase eta.". J. Mol. Biol. 312 (2): 335–46. doi:10.1006/jmbi.2001.4937. PMID 11554790.
Haracska L, Johnson RE, Unk I, et al. (2001). "Physical and functional interactions of human DNA polymerase eta with PCNA.". Mol. Cell. Biol. 21 (21): 7199–206. doi:10.1128/MCB.21.21.7199-7206.2001. PMID 11585903.
Glick E, Vigna KL, Loeb LA (2002). "Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions.". EMBO J. 20 (24): 7303–12. doi:10.1093/emboj/20.24.7303. PMID 11743006.
Limoli CL, Giedzinski E, Bonner WM, Cleaver JE (2002). "UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 233–8. doi:10.1073/pnas.231611798. PMID 11756691.
Broughton BC, Cordonnier A, Kleijer WJ, et al. (2002). "Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 815–20. doi:10.1073/pnas.022473899. PMID 11773631.
Chiapperino D, Kroth H, Kramarczuk IH, et al. (2002). "Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts.". J. Biol. Chem. 277 (14): 11765–71. doi:10.1074/jbc.M112139200. PMID 11821420.
Kusumoto R, Masutani C, Iwai S, Hanaoka F (2002). "Translesion synthesis by human DNA polymerase eta across thymine glycol lesions.". Biochemistry 41 (19): 6090–9. PMID 11994004.
Yavuz S, Yavuz AS, Kraemer KH, Lipsky PE (2002). "The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant.". J. Immunol. 169 (7): 3825–30. PMID 12244178.
Kannouche P, Fernández de Henestrosa AR, Coull B, et al. (2003). "Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.". EMBO J. 21 (22): 6246–56. PMID 12426396.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zheng H, Wang X, Warren AJ, et al. (2003). "Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links.". Mol. Cell. Biol. 23 (2): 754–61. PMID 12509472.
Yang IY, Miller H, Wang Z, et al. (2003). "Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells.". J. Biol. Chem. 278 (16): 13989–94. doi:10.1074/jbc.M212535200. PMID 12584190.
Kannouche P, Fernández de Henestrosa AR, Coull B, et al. (2003). "Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.". EMBO J. 22 (5): 1223–33. doi:10.1093/emboj/cdf618. PMID 12606586.