POLG2

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), gamma 2, accessory subunit

PDB rendering based on 2g4c.

Available structures: 2g4c

Identifiers

Symbol(s)

POLG2; POLB; HP55; MTPOLB; PEOA4; POLGB

External IDs

OMIM: 604983 MGI: 1354947 HomoloGene: 5221

Gene ontology
Molecular Function:	• DNA binding • single-stranded DNA binding • gamma DNA-directed DNA polymerase activity • glycine-tRNA ligase activity • ATP binding • transferase activity • identical protein binding
Cellular Component:	• mitochondrial chromosome • mitochondrion
Biological Process:	• DNA-dependent DNA replication • DNA repair • translation • glycyl-tRNA aminoacylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007215 (mRNA)
NP_009146 (protein)

NM_015810 (mRNA)
NP_056625 (protein)

Location

Chr 17: 59.9 - 59.92 Mb

Chr 11: 106.58 - 106.6 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), gamma 2, accessory subunit, also known as POLG2, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit.

[edit] Further reading

Michiels S, Danoy P, Dessen P, et al. (2007). "Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.". Carcinogenesis 28 (8): 1731–9. doi:10.1093/carcin/bgm111. PMID 17494052.
Huang H, Shiffman ML, Cheung RC, et al. (2006). "Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.". Gastroenterology 130 (6): 1679–87. doi:10.1053/j.gastro.2006.02.032. PMID 16697732.
Longley MJ, Clark S, Yu Wai Man C, et al. (2006). "Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.". Am. J. Hum. Genet. 78 (6): 1026–34. doi:10.1086/504303. PMID 16685652.
Yakubovskaya E, Chen Z, Carrodeguas JA, et al. (2006). "Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.". J. Biol. Chem. 281 (1): 374–82. doi:10.1074/jbc.M509730200. PMID 16263719.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Carrodeguas JA, Pinz KG, Bogenhagen DF (2003). "DNA binding properties of human pol gammaB.". J. Biol. Chem. 277 (51): 50008–14. doi:10.1074/jbc.M207030200. PMID 12379656.
Johnson AA, Tsai Y, Graves SW, Johnson KA (2000). "Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization.". Biochemistry 39 (7): 1702–8. PMID 10677218.
Carrodeguas JA, Bogenhagen DF (2000). "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase.". Nucleic Acids Res. 28 (5): 1237–44. PMID 10666468.
Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance.". J. Biol. Chem. 274 (53): 38197–203. PMID 10608893.
Wang Y, Farr CL, Kaguni LS (1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme.". J. Biol. Chem. 272 (21): 13640–6. PMID 9153213.