POLD1

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), delta 1, catalytic subunit 125kDa

Identifiers

POLD1; CDC2; POLD

External IDs

OMIM: 174761 MGI: 97741 HomoloGene: 2014

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • chromatin binding • DNA-directed DNA polymerase activity • delta DNA polymerase activity • protein binding • zinc ion binding • 3'-5' exonuclease activity • transferase activity • hydrolase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• S phase of mitotic cell cycle • DNA synthesis during DNA repair • DNA replication • base-excision repair, gap-filling • response to UV • DNA replication proofreading

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002691 (mRNA)
NP_002682 (protein)

NM_011131 (mRNA)
NP_035261 (protein)

Location

Chr 19: 55.58 - 55.61 Mb

Chr 7: 44.4 - 44.41 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), delta 1, catalytic subunit 125kDa, also known as POLD1, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa.

[edit] Further reading

Kemper RR, Ahn ER, Zhang P, et al. (1992). "Human DNA polymerase delta gene maps to region 19q13.3-q13.4 by in situ hybridization.". Genomics 14 (1): 205–6. PMID 1427831.
Yang CL, Chang LS, Zhang P, et al. (1992). "Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta.". Nucleic Acids Res. 20 (4): 735–45. PMID 1542570.
Chung DW, Zhang JA, Tan CK, et al. (1992). "Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11197–201. PMID 1722322.
Popanda O, Thielmann HW (1992). "The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.". Biochim. Biophys. Acta 1129 (2): 155–60. PMID 1730053.
Lee MY, Toomey NL (1987). "Human placental DNA polymerase delta: identification of a 170-kilodalton polypeptide by activity staining and immunoblotting.". Biochemistry 26 (4): 1076–85. PMID 2436659.
Dresler SL, Gowans BJ, Robinson-Hill RM, Hunting DJ (1989). "Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.". Biochemistry 27 (17): 6379–83. PMID 3146346.
Nishida C, Reinhard P, Linn S (1988). "DNA repair synthesis in human fibroblasts requires DNA polymerase delta.". J. Biol. Chem. 263 (1): 501–10. PMID 3335506.
Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).". Genomics 44 (1): 45–51. doi:10.1006/geno.1997.4838. PMID 9286699.
Wu SM, Zhang P, Zeng XR, et al. (1998). "Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins.". J. Biol. Chem. 273 (16): 9561–9. PMID 9545286.
Coll JM, Hickey RJ, Cronkey EA, et al. (1998). "Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.". Oncol. Res. 9 (11-12): 629–39. PMID 9563011.
Fox G, Popanda O, Thielmann HW (1998). "Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells.". J. Cancer Res. Clin. Oncol. 123 (11-12): 659–68. PMID 9620226.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Mo J, Liu L, Leon A, et al. (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.". Biochemistry 39 (24): 7245–54. PMID 10852724.
Budworth H, Dianova II, Podust VN, Dianov GL (2002). "Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine.". J. Biol. Chem. 277 (24): 21300–5. doi:10.1074/jbc.M201918200. PMID 11923315.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Smith RW, Nasheuer HP (2002). "Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.". FEBS Lett. 527 (1-3): 143–6. PMID 12220650.
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.". Biochim. Biophys. Acta 1578 (1-3): 59–72. PMID 12393188.
Xie B, Mazloum N, Liu L, et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.". Biochemistry 41 (44): 13133–42. PMID 12403614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Shevelev IV, Ramadan K, Hübscher U (2004). "The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.". ScientificWorldJournal 2: 275–81. doi:10.1100/tsw.2002.99. PMID 12806015.