PMSF
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| PMSF | |
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| IUPAC name | phenylmethanesulfonyl fluoride |
| Identifiers | |
| CAS number | [329-98-6] |
| PubChem | |
| MeSH | |
| SMILES | C1=CC=C(C=C1)CS(=O)(=O)F |
| Properties | |
| Molecular formula | C7H7FO2S |
| Molar mass | 174.194 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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PMSF (phenylmethanesulphonylfluoride or phenylmethylsulphonyl fluoride) is a serine protease inhibitor. However, it does not inhibit all serine proteases. PMSF is rapidly degraded in water and stock solutions are usually made up in anhydrous ethanol, isopropanol, corn oil, or DMSO. Proteolytic inhibition occurs when a concentration between 0.1 - 1 mM PMSF is used. The half-life is small in aqueous solutions (110 min at pH=7 and 35 min at pH=8).
The LD50 (lethal dose) is less than 500mg/kg. PMSF is a cytotoxic chemical which should be handled only inside a fume hood.
The CAS Number is 329-98-6
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