PLXNB2

From Wikipedia, the free encyclopedia

Plexin B2

Identifiers

PLXNB2; MM1; KIAA0315; Nbla00445; PLEXB2; dJ402G11.3

External IDs

OMIM: 604293 MGI: 2154239 HomoloGene: 66630

Gene ontology
Molecular Function:	• molecular_function • receptor activity • protein binding
Cellular Component:	• cellular_component • membrane • integral to membrane
Biological Process:	• multicellular organismal development • biological_process • positive regulation of axonogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_371474 (mRNA)
XP_371474 (protein)

XM_001002428 (mRNA)
XP_001002428 (protein)

Location

Chr 22: 49.06 - 49.07 Mb

Chr 15: 88.98 - 89 Mb

Pubmed search

[1]

[2]

Plexin B2, also known as PLXNB2, is a human gene.^[1]

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PLXNB2 plexin B2.

[edit] Further reading

Shinoura N, Shamraj OI, Hugenholz H, et al. (1995). "Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors.". Cancer Lett. 89 (2): 215-21. PMID 7889532.
Trofatter JA, Long KR, Murrell JR, et al. (1996). "An expression-independent catalog of genes from human chromosome 22.". Genome Res. 5 (3): 214-24. PMID 8593609.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141-50. PMID 9205841.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71-80. PMID 10520995.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.". J. Biol. Chem. 277 (45): 43115-20. doi:10.1074/jbc.M206005200. PMID 12183458.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Artigiani S, Barberis D, Fazzari P, et al. (2003). "Functional regulation of semaphorin receptors by proprotein convertases.". J. Biol. Chem. 278 (12): 10094-101. doi:10.1074/jbc.M210156200. PMID 12533544.
Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells.". J. Biol. Chem. 278 (28): 25671-7. doi:10.1074/jbc.M303047200. PMID 12730235.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Conrotto P, Corso S, Gamberini S, et al. (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth.". Oncogene 23 (30): 5131-7. doi:10.1038/sj.onc.1207650. PMID 15184888.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.