PLXNB1

From Wikipedia, the free encyclopedia

Plexin B1

Identifiers

PLXNB1; KIAA0407; PLEXIN-B1; PLXN5; SEP

External IDs

OMIM: 601053 MGI: 2154238 HomoloGene: 20588

Gene ontology
Molecular Function:	• protein binding • semaphorin receptor activity • semaphorin receptor binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• intracellular signaling cascade • multicellular organismal development • cell migration • positive regulation of axonogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002673 (mRNA)
NP_002664 (protein)

NM_172775 (mRNA)
NP_766363 (protein)

Location

Chr 3: 48.42 - 48.45 Mb

Chr 9: 108.95 - 108.98 Mb

Pubmed search

[1]

[2]

Plexin B1, also known as PLXNB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLXNB1 plexin B1.

[edit] Further reading

Maestrini E, Tamagnone L, Longati P, et al. (1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 674–8. PMID 8570614.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. PMID 10520995.
Vikis HG, Li W, He Z, Guan KL (2001). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner.". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12457–62. doi:10.1073/pnas.220421797. PMID 11035813.
Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMID 11937491.
Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.". Neuron 35 (1): 51–63. PMID 12123608.
Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
Aurandt J, Vikis HG, Gutkind JS, et al. (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12085–90. doi:10.1073/pnas.142433199. PMID 12196628.
Giordano S, Corso S, Conrotto P, et al. (2002). "The semaphorin 4D receptor controls invasive growth by coupling with Met.". Nat. Cell Biol. 4 (9): 720–4. doi:10.1038/ncb843. PMID 12198496.
Hirotani M, Ohoka Y, Yamamoto T, et al. (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.". Biochem. Biophys. Res. Commun. 297 (1): 32–7. PMID 12220504.
Granziero L, Circosta P, Scielzo C, et al. (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes.". Blood 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Artigiani S, Barberis D, Fazzari P, et al. (2003). "Functional regulation of semaphorin receptors by proprotein convertases.". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.". Biochem. Biophys. Res. Commun. 300 (4): 927–31. PMID 12559962.
Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells.". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Conrotto P, Corso S, Gamberini S, et al. (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth.". Oncogene 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.". J. Cell Biol. 165 (6): 869–80. doi:10.1083/jcb.200312094. PMID 15210733.
Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras.". Science 305 (5685): 862–5. doi:10.1126/science.1097545. PMID 15297673.
Conrotto P, Valdembri D, Corso S, et al. (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1.". Blood 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.