PLXNA2

From Wikipedia, the free encyclopedia

Plexin A2

Identifiers

PLXNA2; FLJ11751; FLJ30634; KIAA0463; OCT; PLXN2

External IDs

OMIM: 601054 MGI: 107684 HomoloGene: 56427

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025179 (mRNA)
NP_079455 (protein)

NM_008882 (mRNA)
NP_032908 (protein)

Location

Chr 1: 206.26 - 206.48 Mb

Chr 1: 196.32 - 196.51 Mb

Pubmed search

[1]

[2]

Plexin A2, also known as PLXNA2, is a human gene.^[1]

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.^[1]

[edit] References

^ ^a ^b Entrez Gene: PLXNA2 plexin A2.

[edit] Further reading

Negishi M, Oinuma I, Katoh H (2005). "Plexins: axon guidance and signal transduction.". Cell. Mol. Life Sci. 62 (12): 1363–71. doi:10.1007/s00018-005-5018-2. PMID 15818466.
Maestrini E, Tamagnone L, Longati P, et al. (1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 674–8. PMID 8570614.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.". DNA Res. 4 (5): 345–9. PMID 9455484.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. PMID 10520995.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Mah S, Nelson MR, Delisi LE, et al. (2006). "Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia.". Mol. Psychiatry 11 (5): 471–8. doi:10.1038/sj.mp.4001785. PMID 16402134.
Fujii T, Iijima Y, Kondo H, et al. (2007). "Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population.". Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (4): 873–7. doi:10.1016/j.pnpbp.2007.01.027. PMID 17346868.