PLXNA1

From Wikipedia, the free encyclopedia

Plexin A1

Identifiers

PLXNA1; NOV; NOVP; PLEXIN-A1; PLXN1

External IDs

OMIM: 601055 MGI: 107685 HomoloGene: 56426

Gene ontology
Molecular Function:	• receptor activity • semaphorin receptor activity
Cellular Component:	• cellular_component • membrane • integral to membrane
Biological Process:	• multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032242 (mRNA)
NP_115618 (protein)

NM_008881 (mRNA)
NP_032907 (protein)

Location

Chr 3: 128.19 - 128.24 Mb

Chr 6: 89.28 - 89.33 Mb

Pubmed search

[1]

[2]

Plexin A1, also known as PLXNA1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLXNA1 plexin A1.

[edit] Further reading

Maestrini E, Tamagnone L, Longati P, et al. (1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 674–8. PMID 8570614.
Takahashi T, Fournier A, Nakamura F, et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.". Cell 99 (1): 59–69. PMID 10520994.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. PMID 10520995.
Rohm B, Rahim B, Kleiber B, et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases.". FEBS Lett. 486 (1): 68–72. PMID 11108845.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain.". Neuron 29 (2): 429–39. PMID 11239433.
Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.". J. Neurosci. 22 (2): 471–7. PMID 11784792.
Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMID 12093729.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.". Biochem. Biophys. Res. Commun. 300 (4): 927–31. PMID 12559962.
Bachelder RE, Lipscomb EA, Lin X, et al. (2003). "Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.". Cancer Res. 63 (17): 5230–3. PMID 14500350.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Toyofuku T, Zhang H, Kumanogoh A, et al. (2004). "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2.". Genes Dev. 18 (4): 435–47. doi:10.1101/gad.1167304. PMID 14977921.
Turner LJ, Nicholls S, Hall A (2004). "The activity of the plexin-A1 receptor is regulated by Rac.". J. Biol. Chem. 279 (32): 33199–205. doi:10.1074/jbc.M402943200. PMID 15187088.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.