PLSCR3

From Wikipedia, the free encyclopedia

Phospholipid scramblase 3

Identifiers

External IDs

OMIM: 607611 MGI: 1917560 HomoloGene: 23219

Gene ontology
Molecular Function:	• calcium ion binding • phospholipid scramblase activity
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• phospholipid scrambling • glucose homeostasis • cholesterol homeostasis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020360 (mRNA)
NP_065093 (protein)

XM_001005064 (mRNA)
XP_001005064 (protein)

Location

Chr 17: 7.23 - 7.24 Mb

Chr 11: 69.66 - 69.67 Mb

Pubmed search

[1]

[2]

Phospholipid scramblase 3, also known as PLSCR3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLSCR3 phospholipid scramblase 3.

[edit] Further reading

He Y, Liu J, Grossman D, et al. (2007). "Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid.". J. Cell. Biochem. 101 (5): 1210-21. doi:10.1002/jcb.21243. PMID 17226776.
Van Q, Liu J, Lu B, et al. (2007). "Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells.". Biochem. J. 401 (1): 103-9. doi:10.1042/BJ20060373. PMID 16939411.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Liu J, Dai Q, Chen J, et al. (2004). "Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response.". Mol. Cancer Res. 1 (12): 892-902. PMID 14573790.
Liu J, Chen J, Dai Q, Lee RM (2003). "Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis.". Cancer Res. 63 (6): 1153-6. PMID 12649167.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (2000). "Identification of three new members of the phospholipid scramblase gene family.". Biochim. Biophys. Acta 1467 (1): 244-53. PMID 10930526.