PLSCR1

From Wikipedia, the free encyclopedia

Phospholipid scramblase 1

Identifiers

PLSCR1; MMTRA1B

External IDs

OMIM: 604170 MGI: 893575 HomoloGene: 41418

Gene ontology
Molecular Function:	• calcium ion binding • protein binding • phospholipid scramblase activity
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• response to virus • phospholipid scrambling • platelet activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021105 (mRNA)
NP_066928 (protein)

NM_011636 (mRNA)
NP_035766 (protein)

Location

Chr 3: 147.72 - 147.75 Mb

Chr 9: 92.05 - 92.08 Mb

Pubmed search

[1]

[2]

Phospholipid scramblase 1, also known as PLSCR1, is a human gene.^[1]

[edit] See also

Scramblase

[edit] References

^ Entrez Gene: PLSCR1 phospholipid scramblase 1.

[edit] Further reading

Bassé F, Stout JG, Sims PJ, Wiedmer T (1996). "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid.". J. Biol. Chem. 271 (29): 17205-10. PMID 8663431.
Zhou Q, Zhao J, Stout JG, et al. (1997). "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids.". J. Biol. Chem. 272 (29): 18240-4. PMID 9218461.
Zhou Q, Sims PJ, Wiedmer T (1998). "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.". Biochemistry 37 (8): 2356-60. doi:10.1021/bi972625o. PMID 9485382.
Zhao J, Zhou Q, Wiedmer T, Sims PJ (1998). "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.". Biochemistry 37 (18): 6361-6. doi:10.1021/bi980218m. PMID 9572851.
Kasukabe T, Kobayashi H, Kaneko Y, et al. (1998). "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene.". Biochem. Biophys. Res. Commun. 249 (2): 449-55. doi:10.1006/bbrc.1998.9190. PMID 9712717.
Zhou Q, Zhao J, Al-Zoghaibi F, et al. (2000). "Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha.". Blood 95 (8): 2593-9. PMID 10753839.
Frasch SC, Henson PM, Kailey JM, et al. (2000). "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta.". J. Biol. Chem. 275 (30): 23065-73. doi:10.1074/jbc.M003116200. PMID 10770950.
Tseng CC, Tseng CP (2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement.". FEBS Lett. 475 (3): 232-6. PMID 10869562.
Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (2000). "Identification of three new members of the phospholipid scramblase gene family.". Biochim. Biophys. Acta 1467 (1): 244-53. PMID 10930526.
Sun J, Zhao J, Schwartz MA, et al. (2001). "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.". J. Biol. Chem. 276 (31): 28984-90. doi:10.1074/jbc.M102505200. PMID 11390389.
Silverman RH, Halloum A, Zhou A, et al. (2002). "Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1.". Cancer Res. 62 (2): 397-402. PMID 11809687.
Sun J, Nanjundan M, Pike LJ, et al. (2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.". Biochemistry 41 (20): 6338-45. PMID 12009895.
Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1.". Blood 99 (11): 4030-8. doi:10.1182/blood-2001-12-0271. PMID 12010804.
Xu YC, Wu RF, Gu Y, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.". J. Biol. Chem. 277 (31): 28051-7. doi:10.1074/jbc.M202665200. PMID 12023963.
Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, et al. (2002). "Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes.". Exp. Hematol. 30 (5): 421-9. PMID 12031648.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wiedmer T, Zhao J, Nanjundan M, Sims PJ (2003). "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.". Biochemistry 42 (5): 1227-33. doi:10.1021/bi026679w. PMID 12564925.
Kametaka S, Shibata M, Moroe K, et al. (2003). "Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)).". J. Biol. Chem. 278 (17): 15239-45. doi:10.1074/jbc.M208611200. PMID 12586838.
Rami A, Sims J, Botez G, Winckler J (2003). "Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia.". Neurochem. Int. 43 (1): 79-87. PMID 12605885.
Nanjundan M, Sun J, Zhao J, et al. (2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.". J. Biol. Chem. 278 (39): 37413-8. doi:10.1074/jbc.M306182200. PMID 12871937.