PLS3

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Plastin 3 (T isoform)
PDB rendering based on 1aoa.
Available structures: 1aoa, 1wjo
Identifiers
Symbol(s) PLS3; T-PLASTIN
External IDs OMIM: 300131 MGI: 104807 HomoloGene: 68250
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5358 102866
Ensembl ENSG00000102024 ENSMUSG00000016382
Uniprot P13797 Q3TUZ5
Refseq NM_005032 (mRNA)
NP_005023 (protein)		 XM_978781 (mRNA)
XP_983875 (protein)
Location Chr X: 114.7 - 114.79 Mb Chr X: 72.04 - 72.13 Mb
Pubmed search [1] [2]

Plastin 3 (T isoform), also known as PLS3, is a human gene.[1]

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus.[1]

[edit] References

  1. ^ a b Entrez Gene: PLS3 plastin 3 (T isoform).

[edit] Further reading

  • Lin CS, Aebersold RH, Leavitt J (1990). "Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain.". Mol. Cell. Biol. 10 (4): 1818-21. PMID 2378651. 
  • Lin CS, Aebersold RH, Kent SB, et al. (1989). "Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.". Mol. Cell. Biol. 8 (11): 4659-68. PMID 3211125. 
  • Goldstein D, Djeu J, Latter G, et al. (1985). "Abundant synthesis of the transformation-induced protein of neoplastic human fibroblasts, plastin, in normal lymphocytes.". Cancer Res. 45 (11 Pt 2): 5643-7. PMID 4053036. 
  • Arpin M, Friederich E, Algrain M, et al. (1995). "Functional differences between L- and T-plastin isoforms.". J. Cell Biol. 127 (6 Pt 2): 1995-2008. PMID 7806577. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Lin CS, Shen W, Chen ZP, et al. (1994). "Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney.". Mol. Cell. Biol. 14 (4): 2457-67. PMID 8139549. 
  • Lin CS, Park T, Chen ZP, Leavitt J (1993). "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.". J. Biol. Chem. 268 (4): 2781-92. PMID 8428952. 
  • Goldsmith SC, Pokala N, Shen W, et al. (1997). "The structure of an actin-crosslinking domain from human fimbrin.". Nat. Struct. Biol. 4 (9): 708-12. PMID 9302997. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Shoeman RL, Hartig R, Hauses C, Traub P (2003). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.". Cell Biol. Int. 26 (6): 529-39. PMID 12119179. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Rao RM, Rama S, Rao AJ (2004). "Changes in T-plastin expression with human trophoblast differentiation.". Reprod. Biomed. Online 7 (2): 235-42. PMID 14567899. 
  • Su MW, Dorocicz I, Dragowska WH, et al. (2004). "Aberrant expression of T-plastin in Sezary cells.". Cancer Res. 63 (21): 7122-7. PMID 14612505. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Giganti A, Plastino J, Janji B, et al. (2005). "Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement.". J. Cell. Sci. 118 (Pt 6): 1255-65. doi:10.1242/jcs.01698. PMID 15741236. 
  • Ralser M, Nonhoff U, Albrecht M, et al. (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.". Hum. Mol. Genet. 14 (19): 2893-909. doi:10.1093/hmg/ddi321. PMID 16115810. 
  • Ikeda H, Sasaki Y, Kobayashi T, et al. (2006). "The role of T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.". Int. J. Oncol. 27 (4): 933-40. PMID 16142308. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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