PLN (gene)

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Phospholamban
PDB rendering based on 1fjk.
Available structures: 1fjk, 1fjp, 1n7l, 1zll, 2hyn
Identifiers
Symbol(s)	PLN; CMD1P; PLB
External IDs	OMIM: 172405
Gene ontology Molecular Function: • calcium channel regulator activity • protein binding • ATPase inhibitor activity Cellular Component: • smooth endoplasmic reticulum • membrane • integral to membrane • sarcoplasmic reticulum Biological Process: • cardiac inotropy • cellular calcium ion homeostasis • muscle contraction • circulation • negative regulation of heart contraction • cardiac muscle development • regulation of calcium ion transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5350	n/a
Ensembl	ENSG00000198523	n/a
Uniprot	P26678	n/a
Refseq	NM_002667 (mRNA) NP_002658 (protein)	n/a (mRNA) n/a (protein)
Location	Chr 6: 118.98 - 118.99 Mb	n/a
Pubmed search	[1]	n/a

Phospholamban, also known as PLN, is a human gene.

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.^[1]

[edit] See also

• Phospholamban

[edit] References

[edit] Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.