PLK4

From Wikipedia, the free encyclopedia


Polo-like kinase 4 (Drosophila)
PDB rendering based on 1mby.
Available structures: 1mby
Identifiers
Symbol(s) PLK4; SAK; STK18
External IDs OMIM: 605031 MGI101783 HomoloGene7962
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 10733 20873
Ensembl ENSG00000142731 ENSMUSG00000025758
Uniprot O00444 Q3UVA3
Refseq NM_014264 (mRNA)
NP_055079 (protein)
NM_173169 (mRNA)
NP_775261 (protein)
Location Chr 4: 129.02 - 129.04 Mb Chr 3: 40.9 - 40.91 Mb
Pubmed search [1] [2]

Polo-like kinase 4 (Drosophila), also known as PLK4, is a human gene.[1]

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle.[1]

[edit] References

[edit] Further reading

  • Kleylein-Sohn J, Westendorf J, Le Clech M, et al. (2007). "Plk4-induced centriole biogenesis in human cells.". Dev. Cell 13 (2): 190-202. doi:10.1016/j.devcel.2007.07.002. PMID 17681131. 
  • Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L, et al. (2006). "SAK/PLK4 is required for centriole duplication and flagella development.". Curr. Biol. 15 (24): 2199-207. doi:10.1016/j.cub.2005.11.042. PMID 16326102. 
  • Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA (2006). "The Polo kinase Plk4 functions in centriole duplication.". Nat. Cell Biol. 7 (11): 1140-6. doi:10.1038/ncb1320. PMID 16244668. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Li J, Tan M, Li L, et al. (2005). "SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing.". Neoplasia 7 (4): 312-23. PMID 15967108. 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Macmillan JC, Hudson JW, Bull S, et al. (2002). "Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer.". Ann. Surg. Oncol. 8 (9): 729-40. PMID 11597015. 
  • Yamashita Y, Kajigaya S, Yoshida K, et al. (2001). "Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase.". J. Biol. Chem. 276 (42): 39012-20. doi:10.1074/jbc.M106249200. PMID 11489907. 
  • Hudson JW, Chen L, Fode C, et al. (2000). "Sak kinase gene structure and transcriptional regulation.". Gene 241 (1): 65-73. PMID 10607900. 
  • Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821-30. PMID 8274451.