PLEKHA1

From Wikipedia, the free encyclopedia

Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

PDB rendering based on 1eaz.

Available structures: 1eaz

Identifiers

Symbol(s)

PLEKHA1; TAPP1

External IDs

OMIM: 607772 MGI: 2442213 HomoloGene: 11001

Gene ontology
Molecular Function:	• phospholipid binding
Cellular Component:	• cellular_component • nucleus • membrane
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001001974 (mRNA)
NP_001001974 (protein)

NM_133942 (mRNA)
NP_598703 (protein)

Location

Chr 10: 124.12 - 124.18 Mb

Chr 7: 130.66 - 130.7 Mb

Pubmed search

[1]

[2]

Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1, also known as PLEKHA1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1.

[edit] Further reading

Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.". Biochem. J. 351 (Pt 1): 19–31. PMID 11001876.
Thomas CC, Dowler S, Deak M, et al. (2001). "Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.". Biochem. J. 358 (Pt 2): 287–94. PMID 11513726.
Kimber WA, Trinkle-Mulcahy L, Cheung PC, et al. (2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.". Biochem. J. 361 (Pt 3): 525–36. PMID 11802782.
Marshall AJ, Krahn AK, Ma K, et al. (2002). "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor.". Mol. Cell. Biol. 22 (15): 5479–91. PMID 12101241.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kimber WA, Deak M, Prescott AR, Alessi DR (2003). "Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1.". Biochem. J. 376 (Pt 2): 525–35. doi:10.1042/BJ20031154. PMID 14516276.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Hogan A, Yakubchyk Y, Chabot J, et al. (2005). "The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization.". J. Biol. Chem. 279 (51): 53717–24. doi:10.1074/jbc.M410654200. PMID 15485858.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jakobsdottir J, Conley YP, Weeks DE, et al. (2006). "Susceptibility genes for age-related maculopathy on chromosome 10q26.". Am. J. Hum. Genet. 77 (3): 389–407. doi:10.1086/444437. PMID 16080115.