PLCG1

From Wikipedia, the free encyclopedia

Phospholipase C, gamma 1

PDB rendering based on 1hsq.

Available structures: 1hsq, 1y0m, 1ywo, 1ywp, 2fci, 2hsp, 2pld, 2ple

Identifiers

Symbol(s)

PLCG1; PLC-II; PLC1; PLC148; PLCgamma1

External IDs

OMIM: 172420 MGI: 97615 HomoloGene: 1997

Gene ontology
Molecular Function:	• phosphoinositide phospholipase C activity • signal transducer activity • receptor signaling protein activity • calcium ion binding • protein binding • hydrolase activity
Cellular Component:	• cellular_component
Biological Process:	• in utero embryonic development • intracellular signaling cascade • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002660 (mRNA)
NP_002651 (protein)

NM_021280 (mRNA)
NP_067255 (protein)

Location

Chr 20: 39.2 - 39.24 Mb

Chr 2: 160.42 - 160.47 Mb

Pubmed search

[1]

[2]

Phospholipase C, gamma 1, also known as PLCG1, is a human gene.

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.^[1]