PLCB2

From Wikipedia, the free encyclopedia

Phospholipase C, beta 2

PDB rendering based on 2fju.

Available structures: 2fju

Identifiers

Symbol(s)

PLCB2; FLJ38135

External IDs

OMIM: 604114 MGI: 107465 HomoloGene: 20957

Gene ontology
Molecular Function:	• phosphoinositide phospholipase C activity • signal transducer activity • calcium ion binding • hydrolase activity
Biological Process:	• phospholipid metabolic process • phospholipase C activation • intracellular signaling cascade • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004573 (mRNA)
NP_004564 (protein)

NM_177568 (mRNA)
NP_808236 (protein)

Location

Chr 15: 38.37 - 38.39 Mb

Chr 2: 118.4 - 118.42 Mb

Pubmed search

[1]

[2]

Phospholipase C, beta 2, also known as PLCB2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLCB2 phospholipase C, beta 2.

[edit] Further reading

Park D, Jhon DY, Kriz R, et al. (1992). "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.". J. Biol. Chem. 267 (23): 16048-55. PMID 1644792.
Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117-24. PMID 1979339.
Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695-700. PMID 7589147.
Buhl AM, Osawa S, Johnson GL (1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.". J. Biol. Chem. 270 (34): 19828-32. PMID 7649993.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385-8. PMID 9278385.
Darè E, Kifor O, Brown EM, Weber G (1998). "Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor.". J. Mol. Endocrinol. 21 (1): 7-17. PMID 9723859.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184-92. PMID 9730685.
Park SH, Ryu SH, Suh PG, Kim H (1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 83 (1-2): 48-9. PMID 9925923.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.". J. Neurochem. 73 (4): 1363-74. PMID 10501179.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538-42. PMID 10843712.
Tang Y, Tang J, Chen Z, et al. (2001). "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF.". J. Biol. Chem. 275 (48): 37559-64. doi:10.1074/jbc.M006635200. PMID 10980202.
Caricasole A, Sala C, Roncarati R, et al. (2001). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).". Biochim. Biophys. Acta 1517 (1): 63-72. PMID 11118617.
Singer AU, Waldo GL, Harden TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.". Nat. Struct. Biol. 9 (1): 32-6. doi:10.1038/nsb731. PMID 11753430.
Runnels LW, Yue L, Clapham DE (2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis.". Nat. Cell Biol. 4 (5): 329-36. doi:10.1038/ncb781. PMID 11941371.
Scarlata S (2002). "Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts.". Biochemistry 41 (22): 7092-9. PMID 12033943.
Bertagnolo V, Marchisio M, Pierpaoli S, et al. (2002). "Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors.". J. Leukoc. Biol. 71 (6): 957-65. PMID 12050180.
Barr AJ, Marjoram R, Xu J, Snyderman R (2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3.". Biochem. Biophys. Res. Commun. 293 (1): 647-52. doi:10.1016/S0006-291X(02)00259-0. PMID 12054652.
Buck E, Schatz P, Scarlata S, Iyengar R (2003). "Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2.". J. Biol. Chem. 277 (51): 49707-15. doi:10.1074/jbc.M205553200. PMID 12388553.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174-80. PMID 12482669.