Plasmin

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Plasminogen
PDB rendering based on 1b2i.
Available structures: 1b2i, 1bml, 1bui, 1cea, 1ceb, 1ddj, 1hpj, 1hpk, 1i5k, 1ki0, 1krn, 1l4d, 1l4z, 1pk4, 1pkr, 1pmk, 1qrz, 1rjx, 2doh, 2doi, 2pk4, 5hpg
Identifiers
Symbol(s)	PLG; DKFZp779M0222
External IDs	OMIM: 173350 MGI: 97620 HomoloGene: 55452
Gene ontology Molecular Function: • plasmin activity • calcium ion binding • protein binding • peptidase activity Cellular Component: • extracellular space Biological Process: • proteolysis • apoptosis • induction of apoptosis • blood coagulation • negative regulation of cell proliferation • negative regulation of angiogenesis • tissue regeneration • fibrinolysis • negative regulation of blood vessel endothelial cell migration • myoblast differentiation • muscle maintenance
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5340	18815
Ensembl	ENSG00000122194	ENSMUSG00000059481
Uniprot	P00747	Q3V1T9
Refseq	NM_000301 (mRNA) NP_000292 (protein)	NM_008877 (mRNA) NP_032903 (protein)
Location	Chr 6: 161.04 - 161.09 Mb	Chr 17: 12.22 - 12.26 Mb
Pubmed search	[1]	[2]

Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins, most notable, fibrin clots. The degradation of fibrin is termed fibrinolysis.

Contents 1 Functions 2 Pathology 3 Further reading 4 External links

[edit] Functions

It is a serine protease that is released as plasminogen from the liver into the circulation and activated by tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), thrombin, fibrin, and factor XII (Hageman factor). It is inactivated by alpha 2-antiplasmin, a serine protease inhibitor (serpin).

Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: It activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor.

[edit] Pathology

Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.

[edit] Further reading

[edit] External links

• MeSH Plasmin

v • d • e Proteins: coagulation Coagulation factors primary hemostasis: vWF intrinsic pathway: HMWK/Bradykinin - Kallikrein - Hageman / FXII - FXI - FIX - FVIII extrinsic pathway: Tissue factor / FIII - FVII common pathway: FX - FV - (Pro)thrombin / FII, Fibrin / FI - FXIII Inhibitors Antithrombin (inhibits II, IX, X, XI, XII) - Protein C (inhibits V, VIII)/Protein S (cofactor for protein C) - Protein Z (inhibits X) - ZPI (inhibits X, XI) - TFPI (inhibits III) Fibrinolysis Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - α2-macroglobulin - TAFI

v • d • e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21) Digestive enzymes Enteropeptidase - Trypsin - Chymotrypsin - Elastase (Neutrophil, Pancreatic) Coagulation factors: Thrombin - Factor VIIa - Factor IXa - Factor Xa - Factor XIa - Factor XIIa - Kallikrein (PSA) fibrinolysis: Plasmin - Tissue plasminogen activator - Urinary plasminogen activator Complement system Factor B - Factor D - Factor I - MASP (MASP1, MASP2) - C3-convertase Other immune system Chymase - Granzyme - Tryptase - Proteinase 3/Myeloblastin Venombin Ancrod - Batroxobin Other Acrosin - Prolyl endopeptidase - Pronase - Proprotein convertases (1, 2) - Subtilisin/Furin - Streptokinase - S1P

v • d • e Globulins: beta globulins Angiostatin - Haemopexin - Beta-2 microglobulin - Factor H - Plasminogen - Properdin - Sex hormone binding globulin - Transferrin