Plasmanylethanolamine desaturase

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In enzymology, a plasmanylethanolamine desaturase (EC 1.14.99.19) is an enzyme that catalyzes the chemical reaction

O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH₂ + O₂ $\rightleftharpoons$ O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H₂O

The 3 substrates of this enzyme are O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine, AH2, and O₂, whereas its 3 products are O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxy gen oxidoreductase. Other names in common use include alkylacylglycerophosphoethanolamine desaturase, alkylacylglycero-phosphorylethanolamine dehydrogenase, dehydrogenase, alkyl-acylglycerophosphorylethanolamine, 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase, and 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase. This enzyme participates in ether lipid metabolism. It has 3 cofactors: ATP, Manganese, and Magnesium.

[edit] References

IUBMB entry for 1.14.99.19
BRENDA references for 1.14.99.19 (Recommended.)
PubMed references for 1.14.99.19
PubMed Central references for 1.14.99.19
Google Scholar references for 1.14.99.19
Paltauf F, Holasek A (1973). "Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-8n-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine". J. Biol. Chem. 248: 1609–15. PMID 4144394.
Wykle RL, Blank ML, Malone B, Snyder F (1972). "Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine". J. Biol. Chem. 247: 5442–7. PMID 4403444.