PLAT domain

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PLAT/LH2 domain
Identifiers
Symbol	PLAT
Pfam	PF01477
InterPro	IPR001024
PROSITE	PDOC50095
SCOP	1lpa
OPM family	88
OPM protein	1zq4
Available PDB structures: 1zq4A:374-490 1lox :2-112 1bu8A:356-468 1hplB:351-461 1ethC:339-450 1lpaB:355-465 1gpl :355-465 1n8sA:355-465 1lpbB:355-465 1rp1 :356-467 1y4kA:40-143 2sblB:40-143 1fgoA:40-143 1fgmA:40-143 1yge :40-143 1fgtA:40-143 1f8nA:40-143 1fgqA:40-143 1fgrA:40-143 1rrhA:58-161 1rovA:58-161 1lnh :58-161 1no3A:58-161 1n8qA:58-161 1rrlB:58-161 1hu9A:58-161 1ik3A:58-161 1jnqA:58-161

PLAT domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.

This domain is found in a variety of membrane or lipid associated proteins. It forms a beta-sandwich composed of two sheets of four strands each^[1]^[2]^[3].

[edit] Human proteins containing this domain

ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC; LIPG; LOXHD1; LPL; PKD1; PKD1L1; PKD1L2; PKD1L3; PKDREJ; PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;

[edit] References

^ Bateman A, Sandford R (1999). "The PLAT domain: a new piece in the PKD1 puzzle". Curr. Biol. 9 (16): -. PMID 10469604.
^ Delrieu I, Waller CC, Mota MM, Grainger M, Langhorne J, Holder AA (2002). "PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes". Mol. Biochem. Parasitol. 121 (1): -. PMID 11985859.
^ Minor W, Tomchick DR, Phan P, Cymborowski M, Holman TR (2001). "Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1". Biochemistry 40 (25): 7509-7517. PMID 11412104.