PLAGL2

From Wikipedia, the free encyclopedia

Pleiomorphic adenoma gene-like 2

Identifiers

PLAGL2; FLJ23283

External IDs

OMIM: 604866 MGI: 1933165 HomoloGene: 1994

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • induction of apoptosis • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002657 (mRNA)
NP_002648 (protein)

NM_018807 (mRNA)
NP_061277 (protein)

Location

Chr 20: 30.24 - 30.26 Mb

Chr 2: 152.92 - 152.93 Mb

Pubmed search

[1]

[2]

Pleiomorphic adenoma gene-like 2, also known as PLAGL2, is a human gene.^[1]

Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA.^[1]

[edit] References

^ ^a ^b Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2.

[edit] Further reading

Zheng G, Ning J, Yang YC (2008). "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53.". Biochem. Biophys. Res. Commun. 364 (2): 344-50. doi:10.1016/j.bbrc.2007.10.003. PMID 17950244.
Guo Y, Yang MC, Weissler JC, Yang YS (2007). "PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia.". Biochem. Biophys. Res. Commun. 360 (3): 659-65. doi:10.1016/j.bbrc.2007.06.106. PMID 17618602.
Ammons MC, Siemsen DW, Nelson-Overton LK, et al. (2007). "Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity.". J. Biol. Chem. 282 (24): 17941-52. doi:10.1074/jbc.M610618200. PMID 17462995.
Landrette SF, Kuo YH, Hensen K, et al. (2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11.". Blood 105 (7): 2900-7. doi:10.1182/blood-2004-09-3630. PMID 15585652.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yang MC, Weissler JC, Terada LS, et al. (2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter.". Am. J. Respir. Cell Mol. Biol. 32 (1): 35-43. doi:10.1165/rcmb.2003-0422OC. PMID 15361364.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Furukawa T, Adachi Y, Fujisawa J, et al. (2001). "Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines.". Oncogene 20 (34): 4718-27. doi:10.1038/sj.onc.1204647. PMID 11498794.
Kas K, Voz ML, Hensen K, et al. (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.". J. Biol. Chem. 273 (36): 23026-32. PMID 9722527.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17-24. PMID 8724849.