PLAGL1

From Wikipedia, the free encyclopedia

Pleiomorphic adenoma gene-like 1

Identifiers

PLAGL1; DKFZp781P1017; LOT1; MGC126275; MGC126276; ZAC; ZAC1

External IDs

Gene ontology
Molecular Function:	• nucleic acid binding • DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • induction of apoptosis • cell cycle arrest • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001080951 (mRNA)
NP_001074420 (protein)

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Location

Chr 6: 144.3 - 144.37 Mb

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Pubmed search

[1]

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Pleiomorphic adenoma gene-like 1, also known as PLAGL1, is a human gene.^[1]

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1.

[edit] Further reading

Vernon M (2005). "Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications.". Journal of deaf studies and deaf education 10 (3): 225–31. doi:10.1093/deafed/eni024. PMID 15888725.
Abdollahi A, Roberts D, Godwin AK, et al. (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors.". Oncogene 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.
Abdollahi A, Godwin AK, Miller PD, et al. (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells.". Cancer Res. 57 (10): 2029–34. PMID 9158001.
Spengler D, Villalba M, Hoffmann A, et al. (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain.". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMID 9184226.
Varrault A, Ciani E, Apiou F, et al. (1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. PMID 9671765.
Kas K, Voz ML, Hensen K, et al. (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.". J. Biol. Chem. 273 (36): 23026–32. PMID 9722527.
Abdollahi A, Bao R, Hamilton TC (2000). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein.". Oncogene 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.
Kamiya M, Judson H, Okazaki Y, et al. (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes.". Hum. Mol. Genet. 9 (3): 453–60. PMID 10655556.
Bilanges B, Varrault A, Mazumdar A, et al. (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities.". Oncogene 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.
Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1.". Oncogene 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
Mackay DJ, Coupe AM, Shield JP, et al. (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus.". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319.
Abdollahi A, Pisarcik D, Roberts D, et al. (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hoffmann A, Ciani E, Boeckardt J, et al. (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding.". Mol. Cell. Biol. 23 (3): 988–1003. PMID 12529403.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Ma D, Shield JP, Dean W, et al. (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI200419876. PMID 15286800.
Cvetkovic D, Pisarcik D, Lee C, et al. (2005). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer.". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.
Mitchell J, Punthakee Z, Lo B, et al. (2005). "Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome.". Diabetologia 47 (12): 2160–7. doi:10.1007/s00125-004-1576-3. PMID 15592663.