PLA2G6

From Wikipedia, the free encyclopedia

Phospholipase A2, group VI (cytosolic, calcium-independent)

Identifiers

PLA2G6; PLA2; CaI-PLA2; GVI; INAD1; PNPLA9; iPLA2

External IDs

OMIM: 603604 MGI: 1859152 HomoloGene: 2635

Gene ontology
Molecular Function:	• phospholipase A2 activity • hydrolase activity
Cellular Component:	• cytoplasm • membrane
Biological Process:	• phospholipid metabolic process • cell death • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001004426 (mRNA)
NP_001004426 (protein)

XM_001001101 (mRNA)
XP_001001101 (protein)

Location

Chr 22: 36.84 - 36.91 Mb

Chr 15: 79.11 - 79.16 Mb

Pubmed search

[1]

[2]

Phospholipase A2, group VI (cytosolic, calcium-independent), also known as PLA2G6, is a human gene.^[1]

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.^[1]

[edit] References

^ ^a ^b Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent).

[edit] Further reading

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683–8. PMID 9745929.
Leslie CC (2004). "Regulation of arachidonic acid availability for eicosanoid production.". Biochem. Cell Biol. 82 (1): 1–17. doi:10.1139/o03-080. PMID 15052324.
Turk J, Ramanadham S (2005). "The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells.". Can. J. Physiol. Pharmacol. 82 (10): 824–32. doi:10.1139/y04-064. PMID 15573142.
Law MH, Cotton RG, Berger GE (2006). "The role of phospholipases A2 in schizophrenia.". Mol. Psychiatry 11 (6): 547–56. doi:10.1038/sj.mp.4001819. PMID 16585943.
Tang J, Kriz RW, Wolfman N, et al. (1997). "A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs.". J. Biol. Chem. 272 (13): 8567–75. PMID 9079687.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. PMID 9377118.
Larsson PK, Claesson HE, Kennedy BP (1998). "Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.". J. Biol. Chem. 273 (1): 207–14. PMID 9417066.
Ma Z, Wang X, Nowatzke W, et al. (1999). "Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1.". J. Biol. Chem. 274 (14): 9607–16. PMID 10092647.
Larsson Forsell PK, Kennedy BP, Claesson HE (1999). "The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene.". Eur. J. Biochem. 262 (2): 575–85. PMID 10336645.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Kim SJ, Gershov D, Ma X, et al. (2002). "I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation.". J. Exp. Med. 196 (5): 655–65. PMID 12208880.
Hichami A, Joshi B, Simonin AM, Khan NA (2003). "Role of three isoforms of phospholipase A2 in capacitative calcium influx in human T-cells.". Eur. J. Biochem. 269 (22): 5557–63. PMID 12423354.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cummings BS, McHowat J, Schnellmann RG (2004). "Role of an endoplasmic reticulum Ca2+-independent phospholipase A2 in cisplatin-induced renal cell apoptosis.". J. Pharmacol. Exp. Ther. 308 (3): 921–8. doi:10.1124/jpet.103.060541. PMID 14634037.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bao S, Jin C, Zhang S, et al. (2004). "Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells.". Diabetes 53 Suppl 1: S186–9. PMID 14749286.
Tay HK, Melendez AJ (2004). "Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells.". J. Biol. Chem. 279 (21): 22505–13. doi:10.1074/jbc.M308788200. PMID 15007079.
Tanaka H, Minakami R, Kanaya H, Sumimoto H (2004). "Catalytic residues of group VIB calcium-independent phospholipase A2 (iPLA2gamma).". Biochem. Biophys. Res. Commun. 320 (4): 1284–90. doi:10.1016/j.bbrc.2004.05.225. PMID 15249229.