PLA2G4B

From Wikipedia, the free encyclopedia

Phospholipase A2, group IVB (cytosolic)

Identifiers

PLA2G4B; FLJ42498; HsT16992; cPLA2-beta

External IDs

OMIM: 606088 MGI: 2384819 HomoloGene: 3730

Gene ontology
Molecular Function:	• lysophospholipase activity • calcium ion binding • calcium-dependent phospholipid binding • hydrolase activity • calcium-dependent phospholipase A2 activity
Cellular Component:	• extracellular region • mitochondrion • cytosol • membrane
Biological Process:	• inflammatory response • parturition • lipid catabolic process • arachidonic acid metabolic process • calcium-mediated signaling • glycerophospholipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005090 (mRNA)
NP_005081 (protein)

XM_355378 (mRNA)
XP_355378 (protein)

Location

Chr 15: 39.91 - 39.93 Mb

Chr 2: 119.72 - 119.73 Mb

Pubmed search

[1]

[2]

Phospholipase A2, group IVB (cytosolic), also known as PLA2G4B, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLA2G4B phospholipase A2, group IVB (cytosolic).

[edit] Further reading

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683–8. PMID 9745929.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. PMID 9377118.
Underwood KW, Song C, Kriz RW, et al. (1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2.". J. Biol. Chem. 273 (34): 21926–32. PMID 9705332.
Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2.". J. Biol. Chem. 274 (13): 8823–31. PMID 10085124.
Song C, Chang XJ, Bean KM, et al. (1999). "Molecular characterization of cytosolic phospholipase A2-beta.". J. Biol. Chem. 274 (24): 17063–7. PMID 10358058.
Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.". J. Biol. Chem. 277 (7): 5061–73. doi:10.1074/jbc.M109083200. PMID 11741884.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Ghosh M, Loper R, Gelb MH, Leslie CC (2006). "Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.". J. Biol. Chem. 281 (24): 16615–24. doi:10.1074/jbc.M601770200. PMID 16617059.