PLA2G2D

From Wikipedia, the free encyclopedia

Phospholipase A2, group IID

Identifiers

PLA2G2D; SPLASH; sPLA2S

External IDs

OMIM: 605630 MGI: 1341796 HomoloGene: 7892

Gene ontology
Molecular Function:	• phospholipase A2 activity • calcium ion binding • hydrolase activity
Cellular Component:	• extracellular region
Biological Process:	• phospholipid metabolic process • inflammatory response • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012400 (mRNA)
NP_036532 (protein)

NM_011109 (mRNA)
NP_035239 (protein)

Location

Chr 1: 20.31 - 20.32 Mb

Chr 4: 138.05 - 138.05 Mb

Pubmed search

[1]

[2]

Phospholipase A2, group IID, also known as PLA2G2D, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLA2G2D phospholipase A2, group IID.

[edit] Further reading

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683-8. PMID 9745929.
Leslie CC (2004). "Regulation of arachidonic acid availability for eicosanoid production.". Biochem. Cell Biol. 82 (1): 1-17. doi:10.1139/o03-080. PMID 15052324.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1-9. PMID 9377118.
Ishizaki J, Suzuki N, Higashino K, et al. (1999). "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s.". J. Biol. Chem. 274 (35): 24973-9. PMID 10455175.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Shakhov AN, Rubtsov AV, Lyakhov IG, et al. (2001). "SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency.". Genes Immun. 1 (3): 191-9. doi:10.1038/sj.gene.6363659. PMID 11196711.
Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma.". J. Interferon Cytokine Res. 22 (9): 947-55. doi:10.1089/10799900260286650. PMID 12396716.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Eckey R, Menschikowski M, Lattke P, Jaross W (2005). "Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA.". Inflammation 28 (2): 59-65. PMID 15379211.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Takabatake N, Sata M, Inoue S, et al. (2006). "A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease.". Am. J. Respir. Crit. Care Med. 172 (9): 1097-104. doi:10.1164/rccm.200503-319OC. PMID 16002569.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Lindbom J, Ljungman AG, Tagesson C (2007). "Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide.". Inflammation 29 (2-3): 108-117. doi:10.1007/s10753-006-9007-x. PMID 16897354.