PLA2G12A

From Wikipedia, the free encyclopedia

Phospholipase A2, group XIIA

Identifiers

External IDs

MGI: 1913600 HomoloGene: 11328

Gene ontology
Molecular Function:	• calcium ion binding • hydrolase activity • calcium-dependent phospholipase A2 activity
Cellular Component:	• extracellular region • intracellular • endoplasmic reticulum • Golgi apparatus
Biological Process:	• phospholipid metabolic process • biological_process • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030821 (mRNA)
NP_110448 (protein)

NM_023196 (mRNA)
NP_075685 (protein)

Location

Chr 4: 110.85 - 110.87 Mb

Chr 3: 129.87 - 129.89 Mb

Pubmed search

[1]

[2]

Phospholipase A2, group XIIA, also known as PLA2G12A, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLA2G12A phospholipase A2, group XIIA.

[edit] Further reading

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683-8. PMID 9745929.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rouault M, Bollinger JG, Lazdunski M, et al. (2003). "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity.". Biochemistry 42 (39): 11494-503. doi:10.1021/bi0349930. PMID 14516201.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Murakami M, Masuda S, Shimbara S, et al. (2003). "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).". J. Biol. Chem. 278 (12): 10657-67. doi:10.1074/jbc.M211325200. PMID 12522102.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ho IC, Arm JP, Bingham CO, et al. (2001). "A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells.". J. Biol. Chem. 276 (21): 18321-6. doi:10.1074/jbc.M008837200. PMID 11278438.
Gelb MH, Valentin E, Ghomashchi F, et al. (2001). "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2.". J. Biol. Chem. 275 (51): 39823-6. doi:10.1074/jbc.C000671200. PMID 11031251.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1-9. PMID 9377118.