PLA2G10

From Wikipedia, the free encyclopedia

Phospholipase A2, group X

PDB rendering based on 1le6.

Available structures: 1le6, 1le7

Identifiers

Symbol(s)

PLA2G10; GXPLA2; GXSPLA2; MGC119918; MGC119919; MGC133367; SPLA2

External IDs

OMIM: 603603 MGI: 1347522 HomoloGene: 2636

Gene ontology
Molecular Function:	• phospholipase A2 activity • calcium ion binding • hydrolase activity
Cellular Component:	• extracellular region
Biological Process:	• phospholipid metabolic process • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003561 (mRNA)
NP_003552 (protein)

NM_011987 (mRNA)
NP_036117 (protein)

Location

Chr 16: 14.67 - 14.7 Mb

Chr 16: 13.63 - 13.64 Mb

Pubmed search

[1]

[2]

Phospholipase A2, group X, also known as PLA2G10, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLA2G10 phospholipase A2, group X.

[edit] Further reading

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683-8. PMID 9745929.
Sartipy P, Camejo G, Svensson L, Hurt-Camejo E (2003). "Phospholipase A2 modification of lipoproteins: potential effects on atherogenesis.". Adv. Exp. Med. Biol. 507: 3-7. PMID 12664556.
Murakami M, Kudo I (2004). "New phospholipase A(2) isozymes with a potential role in atherosclerosis.". Curr. Opin. Lipidol. 14 (5): 431-6. doi:10.1097/01.mol.0000092629.86399.d6. PMID 14501581.
Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.". Genomics 33 (1): 151-2. doi:10.1006/geno.1996.0177. PMID 8617505.
Cupillard L, Koumanov K, Mattéi MG, et al. (1997). "Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2.". J. Biol. Chem. 272 (25): 15745-52. PMID 9188469.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1-9. PMID 9377118.
Yokota Y, Higashino K, Nakano K, et al. (2000). "Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor.". FEBS Lett. 478 (1-2): 187-91. PMID 10922494.
Morioka Y, Saiga A, Yokota Y, et al. (2000). "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor.". Arch. Biochem. Biophys. 381 (1): 31-42. doi:10.1006/abbi.2000.1977. PMID 11019817.
Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.". J. Biol. Chem. 277 (7): 5061-73. doi:10.1074/jbc.M109083200. PMID 11741884.
Hanasaki K, Yamada K, Yamamoto S, et al. (2002). "Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation.". J. Biol. Chem. 277 (32): 29116-24. doi:10.1074/jbc.M202867200. PMID 12021277.
Osterström A, Dimberg J, Fransén K, Söderkvist P (2002). "Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas.". Cancer Lett. 182 (2): 175-82. PMID 12048163.
Pan YH, Yu BZ, Singer AG, et al. (2002). "Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.". J. Biol. Chem. 277 (32): 29086-93. doi:10.1074/jbc.M202531200. PMID 12161451.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wooton-Kee CR, Boyanovsky BB, Nasser MS, et al. (2004). "Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.". Arterioscler. Thromb. Vasc. Biol. 24 (4): 762-7. doi:10.1161/01.ATV.0000122363.02961.c1. PMID 14962950.
Mounier CM, Ghomashchi F, Lindsay MR, et al. (2004). "Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.". J. Biol. Chem. 279 (24): 25024-38. doi:10.1074/jbc.M313019200. PMID 15007070.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Masuda S, Murakami M, Takanezawa Y, et al. (2005). "Neuronal expression and neuritogenic action of group X secreted phospholipase A2.". J. Biol. Chem. 280 (24): 23203-14. doi:10.1074/jbc.M500985200. PMID 15781456.