PKMYT1

From Wikipedia, the free encyclopedia

Protein kinase, membrane associated tyrosine/threonine 1

Identifiers

PKMYT1; MYT1; DKFZp547K1610; FLJ20093

External IDs

OMIM: 602474 MGI: 2137630 HomoloGene: 31227

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• membrane fraction • endoplasmic reticulum • Golgi apparatus • membrane
Biological Process:	• regulation of cyclin-dependent protein kinase activity • protein amino acid phosphorylation • cell cycle • regulation of mitosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004203 (mRNA)
NP_004194 (protein)

NM_023058 (mRNA)
NP_075545 (protein)

Location

Chr 16: 2.96 - 2.97 Mb

Chr 17: 23.45 - 23.46 Mb

Pubmed search

[1]

[2]

Protein kinase, membrane associated tyrosine/threonine 1, also known as PKMYT1, is a human gene.^[1]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1.

[edit] Further reading

Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.". Mol. Cell. Biol. 17 (2): 571-83. PMID 9001210.
Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.". J. Biol. Chem. 272 (35): 22300-6. PMID 9268380.
Shen M, Stukenberg PT, Kirschner MW, Lu KP (1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.". Genes Dev. 12 (5): 706-20. PMID 9499405.
Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H (1999). "Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes.". Mol. Cell. Biol. 19 (7): 5113-23. PMID 10373560.
Wells NJ, Watanabe N, Tokusumi T, et al. (1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression.". J. Cell. Sci. 112 ( Pt 19): 3361-71. PMID 10504341.
Pathan N, Aime-Sempe C, Kitada S, et al. (2001). "Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1.". Neoplasia 3 (1): 70-9. doi:10.1038/sj/neo/7900131. PMID 11326318.
Okumura E, Fukuhara T, Yoshida H, et al. (2002). "Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition.". Nat. Cell Biol. 4 (2): 111-6. doi:10.1038/ncb741. PMID 11802161.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Passer BJ, Nancy-Portebois V, Amzallag N, et al. (2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284-9. doi:10.1073/pnas.0530298100. PMID 12606722.
Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E (2003). "Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.". J. Biol. Chem. 278 (28): 25277-80. doi:10.1074/jbc.C300126200. PMID 12738781.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Dai X, Yamasaki K, Yang L, et al. (2004). "Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation.". J. Invest. Dermatol. 122 (6): 1356-64. doi:10.1111/j.0022-202X.2004.22522.x. PMID 15175024.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988-94. doi:10.1038/nature03187. PMID 15616553.
Bryan BA, Dyson OF, Akula SM (2006). "Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency.". J. Gen. Virol. 87 (Pt 3): 519-29. doi:10.1099/vir.0.81603-0. PMID 16476973.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537-47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.