PKIB

From Wikipedia, the free encyclopedia

Protein kinase (cAMP-dependent, catalytic) inhibitor beta

Identifiers

PKIB; FLJ23817; PRKACN2

External IDs

OMIM: 606914 MGI: 101937 HomoloGene: 7474

Gene ontology
Molecular Function:	• cAMP-dependent protein kinase inhibitor activity • kinase activity
Biological Process:	• negative regulation of protein kinase activity

Orthologs

Human

Mouse

Refseq

NM_032471 (mRNA)
NP_115860 (protein)

NM_001039050 (mRNA)
NP_001034139 (protein)

Location

Chr 6: 122.97 - 123.09 Mb

Chr 10: 57.32 - 57.43 Mb

Pubmed search

[1]

[2]

Protein kinase (cAMP-dependent, catalytic) inhibitor beta, also known as PKIB, is a human gene.^[1]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Giangrande PH, Hallstrom TC, Tunyaplin C, et al. (2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.". Mol. Cell. Biol. 23 (11): 3707-20. PMID 12748276.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Qi ZY, Li Y, Ying K, et al. (2002). "Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes.". J. Neurooncol. 56 (3): 197-208. PMID 12061725.
Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors.". Brain Res. Mol. Brain Res. 99 (2): 145-9. PMID 11978406.
Zheng L, Yu L, Tu Q, et al. (2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA.". Biochem. J. 349 (Pt 2): 403-7. PMID 10880337.
Scarpetta MA, Uhler MD (1993). "Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse.". J. Biol. Chem. 268 (15): 10927-31. PMID 7684369.
Van Patten SM, Ng DC, Th'ng JP, et al. (1991). "Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase.". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5383-7. PMID 2052616.