PIWIL1

From Wikipedia, the free encyclopedia

Piwi-like 1 (Drosophila)

Identifiers

PIWIL1; HIWI; PIWI

External IDs

OMIM: 605571 MGI: 1928897 HomoloGene: 37963

Gene ontology
Molecular Function:	• single-stranded RNA binding
Cellular Component:	• cytoplasm • membrane
Biological Process:	• multicellular organismal development • spermatogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004764 (mRNA)
NP_004755 (protein)

XM_974147 (mRNA)
XP_979241 (protein)

Location

Chr 12: 129.39 - 129.42 Mb

Chr 5: 129.05 - 129.07 Mb

Pubmed search

[1]

[2]

Piwi-like 1 (Drosophila), also known as PIWIL1, is a human gene.^[1]

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIWIL1 piwi-like 1 (Drosophila).

[edit] Further reading

Cox DN, Chao A, Baker J, et al. (1999). "A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.". Genes Dev. 12 (23): 3715-27. PMID 9851978.
Sharma AK, Nelson MC, Brandt JE, et al. (2001). "Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.". Blood 97 (2): 426-34. PMID 11154219.
Qiao D, Zeeman AM, Deng W, et al. (2002). "Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas.". Oncogene 21 (25): 3988-99. doi:10.1038/sj.onc.1205505. PMID 12037681.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sasaki T, Shiohama A, Minoshima S, Shimizu N (2004). "Identification of eight members of the Argonaute family in the human genome small star, filled.". Genomics 82 (3): 323-30. PMID 12906857.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Tahbaz N, Kolb FA, Zhang H, et al. (2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.". EMBO Rep. 5 (2): 189-94. doi:10.1038/sj.embor.7400070. PMID 14749716.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Liu X, Sun Y, Guo J, et al. (2006). "Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells.". Int. J. Cancer 118 (8): 1922-9. doi:10.1002/ijc.21575. PMID 16287078.
Taubert H, Greither T, Kaushal D, et al. (2007). "Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma.". Oncogene 26 (7): 1098-100. doi:10.1038/sj.onc.1209880. PMID 16953229.
Sugimoto K, Kage H, Aki N, et al. (2007). "The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.". Biochem. Biophys. Res. Commun. 359 (3): 497-502. doi:10.1016/j.bbrc.2007.05.136. PMID 17544373.