PIP4K2A

From Wikipedia, the free encyclopedia

Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha

Identifiers

PIP5K2A; PIP5KII-alpha; PIPK

External IDs

OMIM: 603140 MGI: 1298206 HomoloGene: 37995

Gene ontology
Molecular Function:	• kinase activity • 1-phosphatidylinositol-4-phosphate 5-kinase activity • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• glycerophospholipid metabolic process • phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005028 (mRNA)
NP_005019 (protein)

XM_985285 (mRNA)
XP_990379 (protein)

Location

Chr 10: 22.86 - 23.04 Mb

Chr 2: 18.76 - 18.92 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha, also known as PIP5K2A, is a human gene.^[1]

Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha.

[edit] Further reading

Loijens JC, Boronenkov IV, Parker GJ, Anderson RA (1996). "The phosphatidylinositol 4-phosphate 5-kinase family.". Adv. Enzyme Regul. 36: 115–40. PMID 8869744.
Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.". Immunity 19 (5): 637–40. PMID 14614850.
Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis.". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/. PMID 15046600.
Tolias KF, Cantley LC, Carpenter CL (1995). "Rho family GTPases bind to phosphoinositide kinases.". J. Biol. Chem. 270 (30): 17656–9. PMID 7629060.
Divecha N, Truong O, Hsuan JJ, et al. (1995). "The cloning and sequence of the C isoform of PtdIns4P 5-kinase.". Biochem. J. 309 ( Pt 3): 715–9. PMID 7639683.
Boronenkov IV, Anderson RA (1995). "The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases.". J. Biol. Chem. 270 (7): 2881–4. PMID 7852364.
Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.". Nature 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Rozenvayn N, Flaumenhaft R (2003). "Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha-granule secretion.". J. Biol. Chem. 278 (10): 8126–34. doi:10.1074/jbc.M206493200. PMID 12509423.
Saito K, Tolias KF, Saci A, et al. (2003). "BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.". Immunity 19 (5): 669–78. PMID 14614854.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Schwab SG, Knapp M, Sklar P, et al. (2006). "Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia.". Mol. Psychiatry 11 (9): 837–46. doi:10.1038/sj.mp.4001864. PMID 16801950.
Bakker SC, Hoogendoorn ML, Hendriks J, et al. (2007). "The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia.". Genes Brain Behav. 6 (2): 113–9. PMID 17410640.
He Z, Li Z, Shi Y, et al. (2007). "The PIP5K2A gene and schizophrenia in the Chinese population--a case-control study.". Schizophrenia Research 94 (1-3): 359–65. doi:10.1016/j.schres.2007.04.013. PMID 17555944.