Pinin

From Wikipedia, the free encyclopedia

Pinin, desmosome associated protein

Identifiers

PNN; DRS; SDK3; memA; pinin

External IDs

OMIM: 603154 MGI: 1100514 HomoloGene: 37656

Gene ontology
Molecular Function:	• DNA binding • structural molecule activity
Cellular Component:	• nucleus • spliceosome • cytoplasm • intermediate filament • plasma membrane • intercellular junction • nuclear speck
Biological Process:	• transcription • regulation of transcription, DNA-dependent • mRNA processing • cell cycle • cell adhesion • RNA splicing • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002687 (mRNA)
NP_002678 (protein)

NM_008891 (mRNA)
NP_032917 (protein)

Location

Chr 14: 38.71 - 38.72 Mb

Chr 12: 59.99 - 59.99 Mb

Pubmed search

[1]

[2]

Pinin, desmosome associated protein, also known as PNN, is a human gene.^[1]

[edit] References

^ Entrez Gene: PNN pinin, desmosome associated protein.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Ouyang P, Sugrue SP (1997). "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex.". J. Cell Biol. 135 (4): 1027–42. PMID 8922384.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Brandner JM, Reidenbach S, Franke WW (1998). "Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein.". Differentiation 62 (3): 119–27. PMID 9447706.
Degen WG, Agterbos MA, Muyrers JP, et al. (1999). "memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3.". Biochim. Biophys. Acta 1444 (3): 384–94. PMID 10095061.
Ouyang P (1999). "Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus.". Biochem. Biophys. Res. Commun. 263 (1): 192–200. doi:10.1006/bbrc.1999.1353. PMID 10486276.
Shi Y, Ouyang P, Sugrue SP (2000). "Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function.". Oncogene 19 (2): 289–97. doi:10.1038/sj.onc.1203328. PMID 10645008.
Shi J, Sugrue SP (2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.". J. Biol. Chem. 275 (20): 14910–5. PMID 10809736.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638.
Wang P, Lou PJ, Leu S, Ouyang P (2002). "Modulation of alternative pre-mRNA splicing in vivo by pinin.". Biochem. Biophys. Res. Commun. 294 (2): 448–55. doi:10.1016/S0006-291X(02)00495-3. PMID 12051732.
Dellaire G, Makarov EM, Cowger JJ, et al. (2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.". Mol. Cell. Biol. 22 (14): 5141–56. PMID 12077342.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chang WL, Lee DC, Leu S, et al. (2003). "Molecular characterization of a novel nucleolar protein, pNO40.". Biochem. Biophys. Res. Commun. 307 (3): 569–77. PMID 12893261.
Li C, Lin RI, Lai MC, et al. (2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1.". Mol. Cell. Biol. 23 (20): 7363–76. PMID 14517304.
Zimowska G, Shi J, Munguba G, et al. (2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells.". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. PMID 14578391.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.". Mol. Cell. Biol. 24 (3): 1174–87. PMID 14729963.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Lin CL, Leu S, Lu MC, Ouyang P (2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles.". Biochem. Biophys. Res. Commun. 321 (3): 638–47. doi:10.1016/j.bbrc.2004.07.013. PMID 15358154.