PIM1

From Wikipedia, the free encyclopedia

Pim-1 oncogene

PDB rendering based on 1xqz.

Available structures: 1xqz, 1xr1, 1xws, 1yhs, 1yi3, 1yi4, 1ywv, 1yxs, 1yxt, 1yxu, 1yxv, 1yxx, 2bik, 2bil, 2bzh, 2bzi, 2bzj, 2bzk, 2c3i, 2j2i, 2o3p, 2o63, 2o64, 2o65, 2obj, 2oi4

Identifiers

Symbol(s)

PIM1; PIM

External IDs

OMIM: 164960 MGI: 97584 HomoloGene: 11214

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity • manganese ion binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein amino acid phosphorylation • multicellular organismal development • cell proliferation • negative regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002648 (mRNA)
NP_002639 (protein)

XM_991765 (mRNA)
XP_996859 (protein)

Location

Chr 6: 37.25 - 37.25 Mb

Chr 17: 29.22 - 29.22 Mb

Pubmed search

[1]

[2]

Pim-1 oncogene, also known as PIM1, is a human gene.^[1]

The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PIM1 pim-1 oncogene.

[edit] Further reading

Ragoussis J, Senger G, Mockridge I, et al. (1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11.". Genomics 14 (3): 673–9. PMID 1427894.
Saris CJ, Domen J, Berns A (1991). "The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.". EMBO J. 10 (3): 655–64. PMID 1825810.
Reeves R, Spies GA, Kiefer M, et al. (1990). "Primary structure of the putative human oncogene, pim-1.". Gene 90 (2): 303–7. PMID 2205533.
Amson R, Sigaux F, Przedborski S, et al. (1989). "The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8857–61. PMID 2682662.
Telerman A, Amson R, Zakut-Houri R, Givol D (1988). "Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity.". Mol. Cell. Biol. 8 (4): 1498–503. PMID 2837645.
Domen J, Von Lindern M, Hermans A, et al. (1988). "Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein.". Oncogene Res. 1 (1): 103–12. PMID 3329709.
Meeker TC, Nagarajan L, ar-Rushdi A, Croce CM (1988). "Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases.". J. Cell. Biochem. 35 (2): 105–12. doi:10.1002/jcb.240350204. PMID 3429489.
Zakut-Houri R, Hazum S, Givol D, Telerman A (1987). "The cDNA sequence and gene analysis of the human pim oncogene.". Gene 54 (1): 105–11. PMID 3475233.
Leverson JD, Koskinen PJ, Orrico FC, et al. (1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity.". Mol. Cell 2 (4): 417–25. PMID 9809063.
Mochizuki T, Kitanaka C, Noguchi K, et al. (1999). "Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway.". J. Biol. Chem. 274 (26): 18659–66. PMID 10373478.
Koike N, Maita H, Taira T, et al. (2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1).". FEBS Lett. 467 (1): 17–21. PMID 10664448.
Maita H, Harada Y, Nagakubo D, et al. (2000). "PAP-1, a novel target protein of phosphorylation by pim-1 kinase.". Eur. J. Biochem. 267 (16): 5168–78. PMID 10931201.
Mizuno K, Shirogane T, Shinohara A, et al. (2001). "Regulation of Pim-1 by Hsp90.". Biochem. Biophys. Res. Commun. 281 (3): 663–9. doi:10.1006/bbrc.2001.4405. PMID 11237709.
Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
Wang Z, Bhattacharya N, Meyer MK, et al. (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells.". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.
Pasqualucci L, Neumeister P, Goossens T, et al. (2001). "Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas.". Nature 412 (6844): 341–6. doi:10.1038/35085588. PMID 11460166.
Ishibashi Y, Maita H, Yano M, et al. (2001). "Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus.". FEBS Lett. 506 (1): 33–8. PMID 11591366.
Rainio EM, Sandholm J, Koskinen PJ (2002). "Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase.". J. Immunol. 168 (4): 1524–7. PMID 11823475.
Nieborowska-Skorska M, Hoser G, Kossev P, et al. (2002). "Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.". Blood 99 (12): 4531–9. PMID 12036885.
Bhattacharya N, Wang Z, Davitt C, et al. (2003). "Pim-1 associates with protein complexes necessary for mitosis.". Chromosoma 111 (2): 80–95. doi:10.1007/s00412-002-0192-6. PMID 12111331.