PIK3R3

From Wikipedia, the free encyclopedia

Phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)

PDB rendering based on 2pna.

Available structures: 2pna, 2pnb

Identifiers

Symbol(s)

PIK3R3; DKFZp686P05226; FLJ41892; p55-GAMMA

External IDs

OMIM: 606076 MGI: 109277 HomoloGene: 2690

Gene ontology
Molecular Function:	• protein binding • kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphoinositide 3-kinase regulator activity • phosphatidylinositol 3-kinase regulator activity
Cellular Component:	• phosphoinositide 3-kinase complex
Biological Process:	• intracellular signaling cascade • insulin receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003629 (mRNA)
NP_003620 (protein)

NM_181585 (mRNA)
NP_853616 (protein)

Location

Chr 1: 46.28 - 46.37 Mb

Chr 4: 115.72 - 115.8 Mb

Pubmed search

[1]

[2]

Phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma), also known as PIK3R3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma).

[edit] Further reading

Pons S, Asano T, Glasheen E, et al. (1995). "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase.". Mol. Cell. Biol. 15 (8): 4453-65. PMID 7542745.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Tuscano JM, Engel P, Tedder TF, et al. (1996). "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.". Eur. J. Immunol. 26 (6): 1246-52. PMID 8647200.
Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.". Oncogene 14 (19): 2273-82. doi:10.1038/sj.onc.1201071. PMID 9178903.
Mothe I, Delahaye L, Filloux C, et al. (1998). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins.". Mol. Endocrinol. 11 (13): 1911-23. PMID 9415396.
Dey BR, Furlanetto RW, Nissley SP (1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.". Gene 209 (1-2): 175-83. PMID 9524259.
Xia X, Serrero G (1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation.". Biochem. J. 341 ( Pt 3): 831-7. PMID 10417350.
Inukai K, Funaki M, Anai M, et al. (2001). "Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.". FEBS Lett. 490 (1-2): 32-8. PMID 11172806.
Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.". Biochem. Biophys. Res. Commun. 299 (5): 793-800. PMID 12470648.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Xia X, Cheng A, Akinmade D, Hamburger AW (2003). "The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest.". Mol. Cell. Biol. 23 (5): 1717-25. PMID 12588990.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Soroceanu L, Kharbanda S, Chen R, et al. (2007). "Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3466-71. doi:10.1073/pnas.0611271104. PMID 17360667.
Kallin A, Johannessen LE, Cani PD, et al. (2007). "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma.". J. Lipid Res. 48 (7): 1628-36. doi:10.1194/jlr.M700136-JLR200. PMID 17452746.