PIGU

From Wikipedia, the free encyclopedia

Phosphatidylinositol glycan anchor biosynthesis, class U

Identifiers

PIGU; GAB1; CDC91L1; MGC40420

External IDs

OMIM: 608528 MGI: 3039607 HomoloGene: 6553

Gene ontology
Molecular Function:	• GPI-anchor transamidase activity • GPI anchor binding
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane • GPI-anchor transamidase complex
Biological Process:	• attachment of GPI anchor to protein

Orthologs

Human

Mouse

Refseq

NM_080476 (mRNA)
NP_536724 (protein)

NM_001004721 (mRNA)
NP_001004721 (protein)

Location

Chr 20: 32.61 - 32.73 Mb

Chr 2: 154.94 - 155.05 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol glycan anchor biosynthesis, class U, also known as PIGU, is a human gene.^[1]

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U.

[edit] Further reading

Ohishi K, Inoue N, Kinoshita T (2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8.". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMID 11483512.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hong Y, Ohishi K, Kang JY, et al. (2004). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.". Mol. Biol. Cell 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMID 12802054.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Vainauskas S, Menon AK (2004). "A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase.". J. Biol. Chem. 279 (8): 6540–5. doi:10.1074/jbc.M312191200. PMID 14660601.
Guo Z, Linn JF, Wu G, et al. (2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer.". Nat. Med. 10 (4): 374–81. doi:10.1038/nm1010. PMID 15034568.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.