PIGQ

From Wikipedia, the free encyclopedia

Phosphatidylinositol glycan anchor biosynthesis, class Q

Identifiers

PIGQ; GPI1; MGC12693; c407A10.1; hGPI1

External IDs

OMIM: 605754 MGI: 1333114 HomoloGene: 31228

Gene ontology
Molecular Function:	• transferase activity, transferring glycosyl groups • phosphatidylinositol N-acetylglucosaminyltransferase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• carbohydrate metabolic process • GPI anchor biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004204 (mRNA)
NP_004195 (protein)

XM_001005461 (mRNA)
XP_001005461 (protein)

Location

Chr 16: 0.56 - 0.57 Mb

Chr 17: 25.65 - 25.67 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol glycan anchor biosynthesis, class Q, also known as PIGQ, is a human gene.^[1]

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).^[1]

[edit] References

^ ^a ^b Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q.

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tiede A, Daniels RJ, Higgs DR, et al. (2001). "The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis.". Gene 271 (2): 247–54. PMID 11418246.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.
Watanabe R, Murakami Y, Marmor MD, et al. (2000). "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.". EMBO J. 19 (16): 4402–11. doi:10.1093/emboj/19.16.4402. PMID 10944123.
Hong Y, Ohishi K, Watanabe R, et al. (1999). "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis.". J. Biol. Chem. 274 (26): 18582–8. PMID 10373468.
Tiede A, Schubert J, Nischan C, et al. (1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants.". Biochem. J. 334 ( Pt 3): 609–16. PMID 9729469.
Watanabe R, Inoue N, Westfall B, et al. (1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.". EMBO J. 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMID 9463366.
Watanabe R, Kinoshita T, Masaki R, et al. (1996). "PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum.". J. Biol. Chem. 271 (43): 26868–75. PMID 8900170.