PIGH

From Wikipedia, the free encyclopedia

Phosphatidylinositol glycan anchor biosynthesis, class H

Identifiers

PIGH; GPI-H

External IDs

OMIM: 600154 MGI: 99463 HomoloGene: 3361

Gene ontology
Molecular Function:	• transferase activity, transferring glycosyl groups • phosphatidylinositol N-acetylglucosaminyltransferase activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• protein modification process • GPI anchor biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004569 (mRNA)
NP_004560 (protein)

NM_029988 (mRNA)
NP_084264 (protein)

Location

Chr 14: 67.13 - 67.14 Mb

Chr 12: 80 - 80.01 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol glycan anchor biosynthesis, class H, also known as PIGH, is a human gene.^[1]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIGH phosphatidylinositol glycan anchor biosynthesis, class H.

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Watanabe R, Inoue N, Westfall B, et al. (1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.". EMBO J. 17 (4): 877-85. doi:10.1093/emboj/17.4.877. PMID 9463366.
Watanabe R, Kinoshita T, Masaki R, et al. (1996). "PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum.". J. Biol. Chem. 271 (43): 26868-75. PMID 8900170.
Kamitani T, Chang HM, Rollins C, et al. (1993). "Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone.". J. Biol. Chem. 268 (28): 20733-6. PMID 8407896.
Ware RE, Howard TA, Kamitani T, et al. (1994). "Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria.". Blood 83 (12): 3753-7. PMID 8204896.