PIGC

From Wikipedia, the free encyclopedia

Phosphatidylinositol glycan anchor biosynthesis, class C

Identifiers

PIGC; GPI2; MGC2049

External IDs

OMIM: 601730 MGI: 1914542 HomoloGene: 7109

Gene ontology
Molecular Function:	• transferase activity, transferring glycosyl groups • phosphatidylinositol N-acetylglucosaminyltransferase activity
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane
Biological Process:	• GPI anchor biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002642 (mRNA)
NP_002633 (protein)

NM_001039045 (mRNA)
NP_001034134 (protein)

Location

Chr 1: 170.63 - 170.68 Mb

Chr 1: 163.81 - 163.81 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol glycan anchor biosynthesis, class C, also known as PIGC, is a human gene.^[1]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIGC phosphatidylinositol glycan anchor biosynthesis, class C.

[edit] Further reading

Eisenhaber B, Maurer-Stroh S, Novatchkova M, et al. (2003). "Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.". Bioessays 25 (4): 367–85. doi:10.1002/bies.10254. PMID 12655644.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Inoue N, Watanabe R, Takeda J, Kinoshita T (1996). "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2.". Biochem. Biophys. Res. Commun. 226 (1): 193–9. doi:10.1006/bbrc.1996.1332. PMID 8806613.
Watanabe R, Kinoshita T, Masaki R, et al. (1996). "PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum.". J. Biol. Chem. 271 (43): 26868–75. PMID 8900170.
Hong Y, Ohishi K, Inoue N, et al. (1997). "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1.". Genomics 44 (3): 347–9. doi:10.1006/geno.1997.4893. PMID 9325057.
Watanabe R, Inoue N, Westfall B, et al. (1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.". EMBO J. 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMID 9463366.
Watanabe R, Murakami Y, Marmor MD, et al. (2000). "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.". EMBO J. 19 (16): 4402–11. doi:10.1093/emboj/19.16.4402. PMID 10944123.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.