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| Picornavirus internal ribosome entry site (IRES) |
 |
| Type: |
Cis-reg; IRES; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
[1] |
| Avg length: |
205.1 nucleotides |
| Avg identity: |
80% |
|
This family represents the Picornavirus internal ribosome entry site (IRES). IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.[1][2]
[edit] References
- ^ Ray, PS; Das S (2002). "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Res 30: 4500–4508. doi:10.1093/nar/gkf583. PMID 12384597.
- ^ Liu, Z; Carthy CM, Cheung P, Bohunek L, Wilson JE, McManus BM, Yang D (1999). "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology 265: 206–217. doi:10.1006/viro.1999.0048. PMID 10600593.
[edit] External links
