PICK1

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Protein interacting with PRKCA 1
PDB rendering based on 2gzv.
Available structures: 2gzv
Identifiers
Symbol(s) PICK1; MGC15204; PRKCABP
External IDs OMIM: 605926 MGI: 894645 HomoloGene: 7470
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9463 18693
Ensembl ENSG00000100151 ENSMUSG00000068206
Uniprot Q9NRD5 Q80VC8
Refseq NM_001039583 (mRNA)
NP_001034672 (protein)		 NM_001045558 (mRNA)
NP_001039023 (protein)
Location Chr 22: 36.78 - 36.8 Mb Chr 15: 79.06 - 79.08 Mb
Pubmed search [1] [2]

Protein interacting with PRKCA 1, also known as PICK1, is a human gene.

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ Entrez Gene: PICK1 protein interacting with PRKCA 1.

[edit] Further reading

  • Collingridge GL, Isaac JT (2003). "Functional roles of protein interactions with AMPA and kainate receptors.". Neurosci. Res. 47 (1): 3–15. PMID 12941441. 
  • Staudinger J, Zhou J, Burgess R, et al. (1995). "PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system.". J. Cell Biol. 128 (3): 263–71. PMID 7844141. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Staudinger J, Lu J, Olson EN (1998). "Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha.". J. Biol. Chem. 272 (51): 32019–24. PMID 9405395. 
  • Torres R, Firestein BL, Dong H, et al. (1999). "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.". Neuron 21 (6): 1453–63. PMID 9883737. 
  • Dev KK, Nishimune A, Henley JM, Nakanishi S (1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits.". Neuropharmacology 38 (5): 635–44. PMID 10340301. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Takeya R, Takeshige K, Sumimoto H (2000). "Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.". Biochem. Biophys. Res. Commun. 267 (1): 149–55. doi:10.1006/bbrc.1999.1932. PMID 10623590. 
  • Cowan CA, Yokoyama N, Bianchi LM, et al. (2000). "EphB2 guides axons at the midline and is necessary for normal vestibular function.". Neuron 26 (2): 417–30. PMID 10839360. 
  • Dev KK, Nakajima Y, Kitano J, et al. (2001). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7.". J. Neurosci. 20 (19): 7252–7. PMID 11007882. 
  • Lin WJ, Chang YF, Wang WL, Huang CY (2001). "Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1.". Biochem. J. 354 (Pt 3): 635–43. PMID 11237868. 
  • Jaulin-Bastard F, Saito H, Le Bivic A, et al. (2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins.". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603. 
  • Torres GE, Yao WD, Mohn AR, et al. (2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.". Neuron 30 (1): 121–34. PMID 11343649. 
  • Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419. 
  • Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons.". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374. 
  • Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).". Biochem. J. 361 (Pt 3): 443–50. PMID 11802773. 
  • Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216. 
  • Perroy J, El Far O, Bertaso F, et al. (2002). "PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.". EMBO J. 21 (12): 2990–9. doi:10.1093/emboj/cdf313. PMID 12065412. 
  • Chen T, Ueda Y, Xie S, Li E (2002). "A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.". J. Biol. Chem. 277 (41): 38746–54. doi:10.1074/jbc.M205312200. PMID 12138111. 
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