PICALM

From Wikipedia, the free encyclopedia

Phosphatidylinositol binding clathrin assembly protein

PDB rendering based on 1hf8.

Available structures: 1hf8, 1hfa, 1hg2, 1hg5

Identifiers

Symbol(s)

PICALM; LAP; CALM; CLTH

External IDs

OMIM: 603025 MGI: 2385902 HomoloGene: 31429

Gene ontology
Molecular Function:	• phospholipid binding • phosphatidylinositol binding • clathrin binding
Cellular Component:	• coated pit
Biological Process:	• protein complex assembly • receptor-mediated endocytosis • hemopoiesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001008660 (mRNA)
NP_001008660 (protein)

NM_146194 (mRNA)
NP_666306 (protein)

Location

Chr 11: 85.35 - 85.46 Mb

Chr 7: 90.01 - 90.07 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a human gene.^[1]

[edit] References

^ Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein.

[edit] Further reading

Ron D, Habener JF (1992). "CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.". Genes Dev. 6 (3): 439-53. PMID 1547942.
Dreyling MH, Martinez-Climent JA, Zheng M, et al. (1996). "The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4804-9. PMID 8643484.
Silliman CC, McGavran L, Wei Q, et al. (1998). "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.". Leukemia 12 (9): 1404-10. PMID 9737689.
Tebar F, Bohlander SK, Sorkin A (1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.". Mol. Biol. Cell 10 (8): 2687-702. PMID 10436022.
Kim JA, Kim SR, Jung YK, et al. (2000). "Properties of GST-CALM expressed in E. coli.". Exp. Mol. Med. 32 (2): 93-9. PMID 10926122.
Wechsler DS, Engstrom LD, Alexander BM, et al. (2003). "A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.". Genes Chromosomes Cancer 36 (1): 26-36. doi:10.1002/gcc.10136. PMID 12461747.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Park SY, Ha BG, Choi GH, et al. (2004). "EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment.". Biochemistry 43 (23): 7552-62. doi:10.1021/bi049970f. PMID 15182197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Meyerholz A, Hinrichsen L, Groos S, et al. (2006). "Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation.". Traffic 6 (12): 1225-34. doi:10.1111/j.1600-0854.2005.00355.x. PMID 16262731.
Archangelo LF, Gläsner J, Krause A, Bohlander SK (2006). "The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10.". Oncogene 25 (29): 4099-109. doi:10.1038/sj.onc.1209438. PMID 16491119.
Deshpande AJ, Cusan M, Rawat VP, et al. (2007). "Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.". Cancer Cell 10 (5): 363-74. doi:10.1016/j.ccr.2006.08.023. PMID 17097559.
Abdelhaleem M, Beimnet K, Kirby-Allen M, et al. (2007). "High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome.". Leukemia 21 (2): 352-3. doi:10.1038/sj.leu.2404503. PMID 17170719.
Ashihara E, Nakamura S, Inaba T, et al. (2007). "A novel AF10-CALM fusion transcript in gamma/delta-T cell type lymphoblastic lymphoma.". Am. J. Hematol. 82 (9): 859-60. doi:10.1002/ajh.21021. PMID 17597474.
Caudell D, Zhang Z, Chung YJ, Aplan PD (2007). "Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice.". Cancer Res. 67 (17): 8022-31. doi:10.1158/0008-5472.CAN-06-3749. PMID 17804713.