PIAS1

From Wikipedia, the free encyclopedia

Protein inhibitor of activated STAT, 1

PDB rendering based on 1v66.

Available structures: 1v66

Identifiers

Symbol(s)

PIAS1; GBP; DDXBP1; GU/RH-II; MGC141878; MGC141879; ZMIZ3

External IDs

OMIM: 603566 MGI: 1913125 HomoloGene: 22953

Gene ontology
Molecular Function:	• DNA binding • transcription coactivator activity • transcription corepressor activity • ATP-dependent RNA helicase activity • protein binding • zinc ion binding • metal ion binding • androgen receptor binding
Cellular Component:	• nucleus
Biological Process:	• transcription • ubiquitin cycle • signal transduction • JAK-STAT cascade • androgen receptor signaling pathway • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016166 (mRNA)
NP_057250 (protein)

NM_019663 (mRNA)
NP_062637 (protein)

Location

Chr 15: 66.17 - 66.27 Mb

Chr 9: 62.68 - 62.78 Mb

Pubmed search

[1]

[2]

Protein inhibitor of activated STAT, 1, also known as PIAS1, is a human gene.^[1]

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1.

[edit] Further reading

Valdez BC, Henning D, Perlaky L, et al. (1997). "Cloning and characterization of Gu/RH-II binding protein.". Biochem. Biophys. Res. Commun. 234 (2): 335-40. doi:10.1006/bbrc.1997.6642. PMID 9177271.
Liu B, Liao J, Rao X, et al. (1998). "Inhibition of Stat1-mediated gene activation by PIAS1.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10626-31. PMID 9724754.
Tan J, Hall SH, Hamil KG, et al. (2000). "Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis.". Mol. Endocrinol. 14 (1): 14-26. PMID 10628744.
Liao J, Fu Y, Shuai K (2000). "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction.". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5267-72. PMID 10805787.
Kotaja N, Aittomäki S, Silvennoinen O, et al. (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.". Mol. Endocrinol. 14 (12): 1986-2000. PMID 11117529.
Gross M, Liu B, Tan J, et al. (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.". Oncogene 20 (29): 3880-7. doi:10.1038/sj.onc.1204489. PMID 11439351.
Liu B, Shuai K (2001). "Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation.". J. Biol. Chem. 276 (39): 36624-31. doi:10.1074/jbc.M101085200. PMID 11451946.
Kahyo T, Nishida T, Yasuda H (2001). "Involvement of PIAS1 in the sumoylation of tumor suppressor p53.". Mol. Cell 8 (3): 713-8. PMID 11583632.
Weiskirchen R, Moser M, Weiskirchen S, et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1.". Biochem. J. 359 (Pt 3): 485-96. PMID 11672422.
Megidish T, Xu JH, Xu CW (2002). "Activation of p53 by protein inhibitor of activated Stat1 (PIAS1).". J. Biol. Chem. 277 (10): 8255-9. doi:10.1074/jbc.C200001200. PMID 11788578.
Schmidt D, Müller S (2002). "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2872-7. doi:10.1073/pnas.052559499. PMID 11867732.
Tan JA, Hall SH, Hamil KG, et al. (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.". J. Biol. Chem. 277 (19): 16993-7001. doi:10.1074/jbc.M109217200. PMID 11877418.
Nishida T, Yasuda H (2003). "PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription.". J. Biol. Chem. 277 (44): 41311-7. doi:10.1074/jbc.M206741200. PMID 12177000.
Rui HL, Fan E, Zhou HM, et al. (2003). "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.". J. Biol. Chem. 277 (45): 42981-6. doi:10.1074/jbc.M208099200. PMID 12223491.
Sapetschnig A, Rischitor G, Braun H, et al. (2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1.". EMBO J. 21 (19): 5206-15. PMID 12356736.
Miyauchi Y, Yogosawa S, Honda R, et al. (2003). "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.". J. Biol. Chem. 277 (51): 50131-6. doi:10.1074/jbc.M208319200. PMID 12393906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ungureanu D, Vanhatupa S, Kotaja N, et al. (2004). "PIAS proteins promote SUMO-1 conjugation to STAT1.". Blood 102 (9): 3311-3. doi:10.1182/blood-2002-12-3816. PMID 12855578.
Kadaré G, Toutant M, Formstecher E, et al. (2004). "PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.". J. Biol. Chem. 278 (48): 47434-40. doi:10.1074/jbc.M308562200. PMID 14500712.
Tallec LP, Kirsh O, Lecomte MC, et al. (2004). "Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification.". Mol. Endocrinol. 17 (12): 2529-42. doi:10.1210/me.2003-0299. PMID 14500761.