PI4KB

From Wikipedia, the free encyclopedia

Phosphatidylinositol 4-kinase, catalytic, beta polypeptide

Identifiers

PIK4CB; PI4K-BETA; PI4KIIIbeta; PI4Kbeta

External IDs

OMIM: 602758 MGI: 1334433 HomoloGene: 6741

Gene ontology
Molecular Function:	• 1-phosphatidylinositol 4-kinase activity • kinase activity • transferase activity • phosphotransferase activity, alcohol group as acceptor
Cellular Component:	• cytoplasm • endosome • endoplasmic reticulum
Biological Process:	• phosphatidylinositol biosynthetic process • receptor-mediated endocytosis • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002651 (mRNA)
NP_002642 (protein)

NM_175356 (mRNA)
NP_780565 (protein)

Location

Chr 1: 149.53 - 149.57 Mb

Chr 3: 95.06 - 95.09 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol 4-kinase, catalytic, beta polypeptide, also known as PIK4CB, is a human gene.^[1]

[edit] References

^ Entrez Gene: PIK4CB phosphatidylinositol 4-kinase, catalytic, beta polypeptide.

[edit] Further reading

Heilmeyer LM, Vereb G, Vereb G, et al. (2004). "Mammalian phosphatidylinositol 4-kinases.". IUBMB Life 55 (2): 59–65. PMID 12749687.
Meyers R, Cantley LC (1997). "Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.". J. Biol. Chem. 272 (7): 4384–90. PMID 9020160.
Wong K, Meyers ddR , Cantley LC (1997). "Subcellular locations of phosphatidylinositol 4-kinase isoforms.". J. Biol. Chem. 272 (20): 13236–41. PMID 9148941.
Suzuki K, Hirano H, Okutomi K, et al. (1998). "Identification and characterization of a novel human phosphatidylinositol 4-kinase.". DNA Res. 4 (4): 273–80. PMID 9405935.
Saito T, Seki N, Ishii H, et al. (1998). "Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene.". DNA Res. 4 (4): 301–5. PMID 9405938.
Sorensen SD, Linseman DA, McEwen EL, et al. (1998). "A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors.". Mol. Pharmacol. 53 (5): 827–36. PMID 9584208.
Godi A, Pertile P, Meyers R, et al. (1999). "ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex.". Nat. Cell Biol. 1 (5): 280–7. doi:10.1038/12993. PMID 10559940.
Suer S, Sickmann A, Meyer HE, et al. (2001). "Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.". Eur. J. Biochem. 268 (7): 2099–106. PMID 11277933.
Zhao X, Várnai P, Tuymetova G, et al. (2001). "Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells.". J. Biol. Chem. 276 (43): 40183–9. doi:10.1074/jbc.M104048200. PMID 11526106.
Balla A, Tuymetova G, Barshishat M, et al. (2002). "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments.". J. Biol. Chem. 277 (22): 20041–50. doi:10.1074/jbc.M111807200. PMID 11923287.
Taverna E, Francolini M, Jeromin A, et al. (2003). "Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.". J. Cell. Sci. 115 (Pt 20): 3909–22. PMID 12244129.
Wei YJ, Sun HQ, Yamamoto M, et al. (2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.". J. Biol. Chem. 277 (48): 46586–93. doi:10.1074/jbc.M206860200. PMID 12324459.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kapp-Barnea Y, Melnikov S, Shefler I, et al. (2004). "Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells.". J. Immunol. 171 (10): 5320–7. PMID 14607934.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Weixel KM, Blumental-Perry A, Watkins SC, et al. (2005). "Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases.". J. Biol. Chem. 280 (11): 10501–8. doi:10.1074/jbc.M414304200. PMID 15634669.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.