PI4KA

From Wikipedia, the free encyclopedia

Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

Identifiers

PIK4CA; FLJ16556; PI4K-ALPHA; pi4K230

External IDs

OMIM: 600286 MGI: 2448506 HomoloGene: 11171

Gene ontology
Molecular Function:	• 1-phosphatidylinositol 4-kinase activity • protein binding • oxidoreductase activity • transferase activity • transition metal ion binding
Cellular Component:	• Golgi-associated vesicle
Biological Process:	• phosphatidylinositol biosynthetic process • signal transduction • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_001131210 (mRNA)
XP_001131210 (protein)

NM_001001983 (mRNA)
NP_001001983 (protein)

Location

Chr 22: 19.39 - 19.54 Mb

Chr 16: 17.19 - 17.32 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide, also known as PIK4CA, is a human gene.^[1]

This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide.

[edit] Further reading

Gehrmann T, Heilmeyer LM (1998). "Phosphatidylinositol 4-kinases.". Eur. J. Biochem. 253 (2): 357–70. PMID 9654085.
Graziani A, Ling LE, Endemann G, et al. (1992). "Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes.". Biochem. J. 284 ( Pt 1): 39–45. PMID 1318025.
Kauffmann-Zeh A, Thomas GM, Ball A, et al. (1995). "Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.". Science 268 (5214): 1188–90. PMID 7761838.
Wong K, Cantley LC (1994). "Cloning and characterization of a human phosphatidylinositol 4-kinase.". J. Biol. Chem. 269 (46): 28878–84. PMID 7961848.
Prasad KV, Kapeller R, Janssen O, et al. (1994). "Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.". Mol. Cell. Biol. 13 (12): 7708–17. PMID 8246987.
Nakagawa T, Goto K, Kondo H (1996). "Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase.". J. Biol. Chem. 271 (20): 12088–94. PMID 8662589.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Berditchevski F, Chang S, Bodorova J, Hemler ME (1997). "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6.". J. Biol. Chem. 272 (46): 29174–80. PMID 9360995.
Gehrmann T, Gülkan H, Suer S, et al. (1999). "Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230.". Biochim. Biophys. Acta 1437 (3): 341–56. PMID 10101268.
Huang C, Handlogten ME, Miller RT (2002). "Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor.". J. Biol. Chem. 277 (23): 20293–300. doi:10.1074/jbc.M200831200. PMID 11907035.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Subrahmanyam G, Rudd CE, Schneider H (2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover.". Eur. J. Immunol. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831.
Carloni V, Mazzocca A, Ravichandran KS (2004). "Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells.". Oncogene 23 (8): 1566–74. doi:10.1038/sj.onc.1207287. PMID 14676841.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
Weixel KM, Blumental-Perry A, Watkins SC, et al. (2005). "Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases.". J. Biol. Chem. 280 (11): 10501–8. doi:10.1074/jbc.M414304200. PMID 15634669.
Israels SJ, McMillan-Ward EM (2005). "CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen.". Thromb. Haemost. 93 (2): 311–8. doi:10.1267/THRO05020311. PMID 15711748.
Waugh MG, Minogue S, Chotai D, et al. (2006). "Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts.". J. Biol. Chem. 281 (7): 3757–63. doi:10.1074/jbc.M506527200. PMID 16249177.