PI4K2A

From Wikipedia, the free encyclopedia

Phosphatidylinositol 4-kinase type II

Identifiers

PI4KII; DKFZP761G1923; RP11-548K23.6

External IDs

OMIM: 609763 MGI: 1934031 HomoloGene: 6239

Gene ontology
Molecular Function:	• magnesium ion binding • 1-phosphatidylinositol 4-kinase activity • protein binding • kinase activity • phosphotransferase activity, alcohol group as acceptor
Cellular Component:	• integral to plasma membrane • lipid raft
Biological Process:	• phosphatidylinositol biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018425 (mRNA)
NP_060895 (protein)

XM_994576 (mRNA)
XP_999670 (protein)

Location

Chr 10: 99.39 - 99.43 Mb

Chr 19: 42.14 - 42.18 Mb

Pubmed search

[1]

[2]

Phosphatidylinositol 4-kinase type II, also known as PI4KII, is a human gene.^[1]

Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PI4KII phosphatidylinositol 4-kinase type II.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Berditchevski F, Tolias KF, Wong K, et al. (1997). "A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.". J. Biol. Chem. 272 (5): 2595–8. PMID 9006891.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Claas C, Stipp CS, Hemler ME (2001). "Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts.". J. Biol. Chem. 276 (11): 7974–84. doi:10.1074/jbc.M008650200. PMID 11113129.
Barylko B, Gerber SH, Binns DD, et al. (2001). "A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans.". J. Biol. Chem. 276 (11): 7705–8. doi:10.1074/jbc.C000861200. PMID 11244087.
Minogue S, Anderson JS, Waugh MG, et al. (2001). "Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family.". J. Biol. Chem. 276 (20): 16635–40. doi:10.1074/jbc.M100982200. PMID 11279162.
Wei YJ, Sun HQ, Yamamoto M, et al. (2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.". J. Biol. Chem. 277 (48): 46586–93. doi:10.1074/jbc.M206860200. PMID 12324459.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Waugh MG, Minogue S, Anderson JS, et al. (2003). "Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum.". Biochem. J. 373 (Pt 1): 57–63. doi:10.1042/BJ20030089. PMID 12650639.
Wang YJ, Wang J, Sun HQ, et al. (2003). "Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi.". Cell 114 (3): 299–310. PMID 12914695.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.