Physalaemin
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| Physalaemin | |
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| Identifiers | |
| CAS number | [2507-24-6] |
| PubChem | |
| MeSH | |
| Properties | |
| Molecular formula | C58H84N14O16S |
| Molar mass | 1265.44 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.[1][2]
Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects.[3]
[edit] References
- ^ Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia 20 (9): 489–90. PMID 5857249.
- ^ Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys 108: 341–8. PMID 14240587.
- ^ Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev 54 (2): 285–322. PMID 12037144. Free full text
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