Phthalyl amidase

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In enzymology, a phthalyl amidase (EC 3.5.1.79) is an enzyme that catalyzes the chemical reaction

a phthalylamide + H₂O $\rightleftharpoons$ phthalic acid + a substituted amine

Thus, the two substrates of this enzyme are phthalylamide and H₂O, whereas its two products are phthalic acid and substituted amine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is phthalyl-amide amidohydrolase.

[edit] References

IUBMB entry for 3.5.1.79
BRENDA references for 3.5.1.79 (Recommended.)
PubMed references for 3.5.1.79
PubMed Central references for 3.5.1.79
Google Scholar references for 3.5.1.79
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Zmijewski MJ (1996). "o-Phthalyl amidase in the synthesis of Loracarbef: process development using this novel biocatalyst". Biotechnol. Lett. 18: 875–880. doi:10.1007/BF00154613.
Costello C, Kreuzman A, Zmijewski M (1996). "Selective deprotection of phthalyl protected proteins". Tetrahedron Lett. 37: 7469–7472.
Briggs BS, Zmijewski MJ (1995). "Enzyme from microbial source: phthalyl amidase". Chem. Abstr. 123: 25010.