Phosphoribosylformylglycinamidine cyclo-ligase

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In enzymology, a phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) is an enzyme that catalyzes the chemical reaction

ATP + 2-(formamido)-N₁-(5-phospho-D-ribosyl)acetamidine $\rightleftharpoons$ ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole

Thus, the two substrates of this enzyme are ATP and 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine, whereas its 3 products are ADP, phosphate, and 5-amino-1-(5-phospho-D-ribosyl)imidazole.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming). Other names in common use include phosphoribosylaminoimidazole synthetase, AIR synthetase, 5'-aminoimidazole ribonucleotide synthetase, 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase, and (ADP-forming). This enzyme participates in purine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1CLI, 2BTU, 2QK4, and 2V9Y.

[edit] References

IUBMB entry for 6.3.3.1
BRENDA references for 6.3.3.1 (Recommended.)
PubMed references for 6.3.3.1
PubMed Central references for 6.3.3.1
Google Scholar references for 6.3.3.1
LEVENBERG B, BUCHANAN JM (1957). "Biosynthesis of the purines. XII. Structure, enzymatic synthesis, and metabolism of 5-amino-imidazole ribotide". J. Biol. Chem. 224: 1005–18. PMID 13405929.
LEVENBERG B, BUCHANAN JM (1957). "Biosynthesis of the purines. XIII. Structure, enzymatic synthesis, and metabolism of (alpha-N-formyl)-glycinamidine ribotide". J. Biol. Chem. 224: 1019–27. PMID 13405930.