Phosphoribosylamine-glycine ligase

From Wikipedia, the free encyclopedia

In enzymology, a phosphoribosylamine-glycine ligase (EC 6.3.4.13) is an enzyme that catalyzes the chemical reaction

ATP + 5-phospho-D-ribosylamine + glycine $\rightleftharpoons$ ADP + phosphate + N₁-(5-phospho-D-ribosyl)glycinamide

The 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-(5-phospho-D-ribosyl)glycinamide.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-phospho-D-ribosylamine:glycine ligase (ADP-forming). Other names in common use include phosphoribosylglycinamide synthetase, glycinamide ribonucleotide synthetase, phosphoribosylglycineamide synthetase, glycineamide ribonucleotide synthetase, 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase, 5'-phosphoribosylglycinamide synthetase, and GAR. This enzyme participates in purine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1GSO, 1VKZ, and 2QK4.

[edit] References

IUBMB entry for 6.3.4.13
BRENDA references for 6.3.4.13 (Recommended.)
PubMed references for 6.3.4.13
PubMed Central references for 6.3.4.13
Google Scholar references for 6.3.4.13
GOLDTHWAIT DA, GREENBERG GR, PEABODY RA (1956). "On the mechanism of synthesis of glycinamide ribotide and its formyl derivative". J. Biol. Chem. 221: 569–77. PMID 13357451.
HARTMAN SC, BUCHANAN JM (1958). "Biosynthesis of the purines. XXII 2-Amino-N-ribosylacetamide-5'-phosphate kinosynthase". J. Biol. Chem. 233: 456–61. PMID 13563520.